Microsatellite instability

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Unknown (3234)
Transcriptomics (2066)
Genomics (285)
Proteomics (143)
Clinical (82)
Methylation profiling (10)
Other (6)
Metabolomics (2)
Genomic (1)

Organisms

Homo sapiens (1116)
Mus musculus (463)
Saccharomyces cerevisiae (72)
Arabidopsis thaliana (57)
Rattus norvegicus (51)
Drosophila melanogaster (35)
Danio rerio (29)
Sus scrofa (25)
Zea mays (14)
Caenorhabditis elegans (14)
Gallus gallus (14)
Escherichia coli (11)
Bacillus subtilis subsp. subtilis str. 168 (8)
Oryza sativa (8)
Oryza sativa Japonica Group (8)
synthetic construct (7)
Vibrio harveyi (6)
Schizosaccharomyces pombe (6)
Bacillus subtilis (6)
Staphylococcus aureus (6)
Bos taurus (6)
Escherichia coli str. K-12 substr. MG1655 (6)
Brassica napus (4)
Medicago truncatula (4)
Plasmodium falciparum 3D7 (4)
Fagus sylvatica (4)
Oncorhynchus mykiss (4)
Plasmodium falciparum (4)
Escherichia coli K-12 (4)
Lactococcus lactis (3)

Organisms

Homo sapiens (107)
Mus musculus (21)
Macaca mulatta (2)
human feces metagenome (1)
human gut metagenome (1)

Repository

biostudies-arrayexpress (2056)
ENA (199)
geo (103)
PeptideAtlas (95)
EGA (28)
pride (13)
MassIVE (12)
iProX (3)
MetaboLights (2)
dbGaP (1)
jPOST (1)

Tissue

Digestive System (95)
Colon (7)
Epithelial cell (4)
Cell culture (2)
Colon epithelial cell (1)
HEK-293T cell (1)

Disease

Colorectal Neoplasms (45)
Colon cancer (9)
Neoplasms (6)
Colorectal cancer (5)
Carcinoma (5)
Colorectal cancer (3)
Normal (2)
Mesothelioma (2)
Colorectal Neoplasms, Hereditary Nonpolyposis (2)
Endometrial Neoplasms (2)
Adenocarcinoma (2)
Lung Neoplasms (2)
Testicular seminoma (1)
Papillary renal cell carcinoma (1)
High grade glioblastoma (1)
Cocaine addiction (1)
Ewing family tumor (1)
Uninfected (1)
Schizophrenia (1)
Colorectal carcinoma (1)
Glioblastoma (1)
Adenocarcinoma (1)
Multiple myeloma (1)
COLORECTAL METASTATIC CANCER WITH MICROSATELLITE INSTABILITY (MSI) (1)
Colorectal cancer stage IV (1)
Neoplasms by Site (1)
Carcinoma, Ovarian Epithelial (1)
Metastatic colorectal cancer with microsatellite instability high (MSI-H) mismatch repair deficient (MMR-D) (1)
1) Malignant melanoma 2) Non-small cell lung cancer 3) Renal cell carcinoma 4) Classical hodgkin lymphoma 5) Squamous cell carcinoma of the head and neck 6) Gastric cancer 7) Urothelial carcinoma 8) Malignant pleural mesothelioma 9) Microsatellite instability-high cancer 10) Extensive-stage small cell lung cancer 11) Triple-negative breast cancer with PD-L1 expression 12) Microsatellite instability-high metastatic colorectal cancer 13) Esophageal cancer (1)
BRAF V600E mutant metastatic colorectal cancer (1)

Technology Type

Mass Spectrometry (13)
Shotgun proteomics (9)
ILLUMINA, Illumina HiSeq 2500 (3)
Data-dependent acquisition (3)
Complete Genomics, Illumina HiSeq 2000 (1)
Affymetrix SNP 6.0, Illumina Genome Analyzer IIx (1)
Complete Genomics, Complete Genomics - CG Build 1.4.2.8 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer IIx (1)
Mass spectrometry (1)
Mass spectrometry assay (1)
Affinity purification coupled with mass spectrometry proteomics (1)
Bottom-up proteomics (1)
HDMSE (1)
Immunopeptidomics (1)
SRM/MRM (1)

Instrument Platform

LTQ Orbitrap Velos (107)
NextSeq 500 (12)
Illumina NovaSeq 6000 (8)
Illumina HiSeq 2000 (7)
Illumina HiSeq 4000 (7)
NextSeq 550 (3)
Liquid Chromatography MS - negative - reverse phase (2)
Liquid Chromatography MS - positive - reverse phase (2)
Agilent 2100 Bioanalyzer, Applied Biosystems 7900HT Sequence Detection System, Illumina TruSeq Small RNA Sample Preparation Kit (1)
RNeasy mini Kit, Ribo-Zero Human/Mouse/Rat kit (1)
GeneSpring software V12 (Agilent) (1)
Helicos (1)
Agilent 2100 Bioanalyzer (1)
ScanArray 4000XL [PerkinElmer] (1)
10x Genomics Chromium Controller (1)
Illumina iSeq 100 (1)
Illumina MiSeq (1)
Illumina HiSeq 1500 (1)

Publication Date

2010 (353)
2015 (322)
2014 (304)
2013 (283)
2012 (264)
2011 (246)
2016 (106)
2008 (92)
2009 (89)
2022 (41)
2007 (39)
2021 (18)
2005 (17)
2026 (17)
2006 (15)
2023 (13)
2025 (12)
2024 (12)
2020 (9)
2017 (8)
2019 (7)
2004 (4)
2002 (2)
2003 (1)
2018 (1)

UNIPROT ID/AC

A0A024RC46 (95)
A0A087WTX5 (95)
A0A087WVW2 (95)
A0A087WXI0 (95)
A0A087WYL9 (95)
A0A087X130 (95)
A0A087X1V9 (95)
A0A0A0MS07 (95)
A0A0A0MS51 (95)
A0A0B4J1V0 (95)
A0A0C4DG89 (95)
A0AVT1 (95)
A0FGR8 (95)
A0FGR8-2 (95)
A0FGR8-6 (95)
A0M8Q6 (95)
A0N5G5 (95)
A1L0T0 (95)
A2BFH1 (95)
A2IPI2 (95)
A2IPI5 (95)
A2NB46 (95)
A2NKM6 (95)
A2NUT2 (95)
A2NXP9 (95)
A4F255 (95)
A5A3E0 (95)
A6NHL2 (95)
A6NNZ2 (95)
A8MTJ3 (95)

ENSEMBL ID

ENSG00000170477 (95)
ENSG00000229353 (47)
ENSG00000147251 (18)
ENSG00000176092 (2)
ENSG00000247315 (1)

Metabolite Name

PppGpp (1)
(+/-)-(e)-4-Ethyl-2-[(z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (1)
PA(14:0/6 keto-PGF1alpha) (1)
PA(i-12:0/PGF1alpha) (1)
PGP(22:6-OH/i-12:0) (1)
8-Anilino-5-(4-anilino-5-sulfonaphthalen-1-yl)naphthalene-1-sulfonic acid (1)
Leptosine (1)
PG(20:3-2OH/20:1) (1)
Cer(d20:1/PGE2) (1)
1-(4-(5-Maleimidopentyl)aminobenzyl)ethylenediaminetetraacetic acid (1)
N-Acetylamrinone (1)
PG(18:3/PGJ2) (1)
Baloxavir marboxil (1)
Pentadeca-3,6,9-trienedioylcarnitine (1)
Cryptophycin 52 (1)
4-[[4-Amino-6-(2,4,6-trimethylanilino)-1,3,5-triazin-2-yl]amino]benzonitrile (1)
Tyrphostin AG 825 (1)
4'-Iododoxorubicinol (1)
Glyceryl Monooleate (1)
2-Hydroxybutanebis(thioic S-acid) (1)
PE(18:4/20:5-OH) (1)
PC(22:6-2OH(7S, 17S)/DiMe) (1)
DG(18:3/22:1/0:0)[iso2] (1)
PE-NMe(22:6/18:4) (1)
1,2-Diphenyl-4-(2''-phenylsulfinethyl)-3,5-pyrazolidinedione (1)
Cyclopentenylcytosine 6-triphosphate (1)
1-Azidosulfanylnonane (1)
[(2S,3R,5S,6S)-2,3,4,5,6-Pentaphosphonooxycyclohexyl] phosphanyl hydrogen phosphate (1)
3-Methylthiophene (1)
PA(TXB2/12:0) (1)

First Public Date

2024 (27)
2014 (25)
2025 (23)
2023 (23)
2022 (22)
2026 (20)
2021 (16)
2019 (15)
2020 (9)
2017 (8)
2018 (7)
2015 (3)
2016 (1)

Study status

Recruiting (28)
Completed (21)
Active, not recruiting (12)
Not provided (8)
Not yet recruiting (7)
Terminated (3)
Withdrawn (2)
Ongoing (1)

Study type

Transcription profiling by array (1178)
RNA-seq of coding RNA (273)
RNA-seq of non coding RNA (112)
Comparative genomic hybridization by array (97)
Unknown experiment type (89)
Other (80)
Interventional (57)
Methylation profiling by array (50)
ChIP-chip by tiling array (35)
Transcription profiling by tiling array (27)
ChIP-seq (27)
Observational (24)
Proteomic profiling by array (19)
Genotyping by array (16)
Transcription profiling by RT-PCR (10)
Transcription profiling by SAGE (8)
DNA-seq (7)
Animal - High-throughput sequencing (4)
ChIP-chip by array (4)
MicroRNA profiling by array (4)
RNA-seq of coding RNA from single cells (4)
Human - High-throughput sequencing (2)
Human - One-color microarray (2)
Methylation profiling by high throughput sequencing (2)
Animal - One-color microarray (1)
Animal - Single-cell sequencing (1)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
RNAi profiling by array (1)
ATAC-seq (1)

Release Date

2022 (566)
2023 (486)
2021 (394)
2010 (391)
2015 (383)
2013 (327)
2024 (315)
2025 (309)
2012 (303)
2011 (272)
2014 (259)
2020 (250)
2016 (194)
2019 (192)
2018 (126)
2008 (114)
2009 (111)
2017 (110)
2007 (46)
2026 (35)
2005 (34)
2006 (21)
2001 (12)
2004 (10)
2003 (9)
2002 (8)
1999 (6)
2000 (5)
1998 (2)

Lab affiliation

Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Cambridge Institute for Medical Research (CIMR), Department of Genomic Medicine, University of Cambridge, Cambridge CB2 0XY (1)
Department of Cancer Cell Signaling, Boehringer Ingelheim Vienna (1)
Department of Genome Engineering, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznan, 61-704, Poland (1)
Dept. Applied Tumor Biology Institute of Pathology Im Neuenheimer Feld 224 69120 Heidelberg Germany (1)
Memorial Sloan Kettering Cancer Center, Department of pathology (1)
Molecular Medicine Partnership Unit (MMPU), Heidelberg University & European Molecular Biology Laboratory (EMBL) Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University & Hopp Children’s Cancer Center, National Center for Tumor Diseases (NCT) (1)
Molecular Oncology Lab, La Paz University Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain (1)
PI, Dept. Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg (1)
Vanderbilt University Proteomics Core (1)
Vice Director, Professor Novo Nordisk Foundation Center for Protein Research Proteomics Program University of Copenhagen Faculty of Health and Medical Sciences Blegdamsvej 3b DK-2200 Copenhagen Denmark (1)

Location

United States (30)
China (24)
France (17)
Italy (12)
Spain (12)
Canada (12)
Germany (11)
United Kingdom (11)
Netherlands (10)
Japan (10)
South Korea (9)
Belgium (9)
Australia (9)
Taiwan (6)
Norway (5)
Singapore (5)
Turkey (5)
Chile (5)
Poland (5)
Israel (5)
Brazil (5)
Denmark (4)
Czechia (4)
Sweden (4)
Hong Kong (3)
South Africa (3)
Ireland (3)
New Zealand (3)
Mexico (3)
Argentina (3)

Keyword

Pembrolizumab (14)
Nivolumab (7)
Immunotherapy (7)
Bevacizumab (7)
Atezolizumab (6)
Irinotecan (5)
Ipilimumab (4)
Antibodies (4)
Cetuximab (4)
Programmed Cell Death-1 (PD1, PD-1) (3)
Programmed Death-Ligand 1 (PDL1, PD-L1) (3)
MSI-H (3)
Immune Checkpoint Inhibitors (3)
Tislelizumab (3)
Rectal cancer (3)
Oxaliplatin (3)
Mismatch repair (2)
Microsatellite instability (2)
Cyclooxygenase Inhibitors (2)
Cyclophosphamide (2)
Fludarabine (2)
Immunohistochemistry (2)
Stage I rectal cancer (2)
Temozolomide (2)
DMMR (2)
Regorafenib (2)
Durvalumab (2)
Stage I colon cancer (2)
Avelumab (2)
CRC (2)

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Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

Despite the encouraging efficacy of anti-PD-1/PD-L1 immunotherapy in microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) advanced gastrointestinal cancer, many patients exhibit primary or acquired resistance. Using multi-omics approaches, we interrogated gut microbiome, blood meta...

2026-07-16 | MTBLS9021 | MetaboLights

Colorectal cancers with microsatellite instability display unique miRNA profiles

Analysis of microRNA expression of tumoral and non-tumoral colonic tissues. The aim of this study was to analyze the global miRNA signatures in various groups of well-characterized CRCs based on the presence of microsatellite instability (MSI). Total RNA from formalin-fixed paraffin-embedded tissue ...

ORGANISM(S): Homo sapiens

2011-11-22 | E-GEOD-30454 | biostudies-arrayexpress

Microsatellite instability analysis of sebaceous neoplasia

PRJEB79222 | ENA

High-resolution genetic analysis of cancer cell lines with near normal karyotypes

Cancer development is associated with multiple genetic alterations and genomic instability either at the chromosomal or base pair level is generally thought to underlie these changes. However, it is still unknown whether genetic instability is absolutely required for tumorigenesis. Here we investig...

ORGANISM(S): Homo sapiens

2008-03-14 | E-GEOD-8649 | biostudies-arrayexpress

MicroRNA profiling of human colorectal cancer samples with high microsatellite instability

Background. Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results. We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and 16 by high microsatellite instability, MSI-H)...

ORGANISM(S): Homo sapiens

2007-09-07 | E-TABM-326 | biostudies-arrayexpress

A new classification of chromosome instability (CIN) phenotype, CIN-high and CIN-low

Samples were taken from colorectal cancers in surgically resected specimens in 35 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be u...

ORGANISM(S): Homo sapiens

2012-07-03 | E-GEOD-30540 | biostudies-arrayexpress

Expression data from human MSI colorectal cancer and normal colonic mucosa

Microsatellite instability (MSI), caused by defective mismatch repair, is observed in a subset of colorectal cancers (CRCs). We evaluated somatic mutations in microsatellite repeats of genes chosen based on reduced expression in MSI CRC and existence of a coding mononucleotide repeat. Expression pro...

ORGANISM(S): Homo sapiens

2011-03-01 | E-GEOD-24514 | biostudies-arrayexpress

Fecal samples of microsatellite instability-high cancer patients

Fecal samples of microsatellite instability-high cancer patients Raw sequence reads

PRJNA1042925 | ENA

Gastric cancers of Western European and African patients

Gastric cancer is the second most common cause of cancer death worldwide, but incidence and mortality rates show large variations across different countries. Variation in risk factors between different populations, including environmental and host factors influencing gastric cancer risk, have been r...

ORGANISM(S): Homo sapiens

2011-06-27 | E-GEOD-22789 | biostudies-arrayexpress

Transcription profiling of human colorectal cancers with and without microsatellite instability identifies a set of discriminating genes and identifies proximal and distal cancers

Samples were taken from colorectal cancers in surgically resected specimens in 84 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes between MSI a...

ORGANISM(S): Homo sapiens

2008-06-13 | E-GEOD-4554 | biostudies-arrayexpress

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