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ProteomicsKIF1A Motor-Neck domain interaction
Quantitative Analysis of Motor-Neck Interaction by the Combination of Protein Painting and Stable Isotope Tags Labelling
ORGANISM(S): Sus Scrofa 
2021-12-23 | PXD026083 | JPOST Repository
TranscriptomicsGene expression in cellular compartments of Aplysia motor neurons
Whole genome transcriptional profiling is used to compare ESTs found in cell bodies and processes of Aplysia motor neurons RNA samples derived from cell bodies or processes of Aplysia single cultured motor neurons were hybridized to custom Aplysia EST microarrays. Two-condition experiment; four biol...
ORGANISM(S): Aplysia californica 
2013-04-26 | E-GEOD-30387 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in motor pools with differential vulnerability in ALS
ALS is a uniformly fatal neurodegenerative disease in which motor neurons in the spinal cord and brain stem are selectively lost. Individual motor - groups of motor neurons innervating single muscles - show widely varying degrees of disease resistance: in the final stages of ALS, nearly all voluntar...
ORGANISM(S): Mus musculus 
2013-11-15 | E-GEOD-52118 | biostudies-arrayexpress
ProteomicsMechanochemical tuning of a kinesin motor essential for malaria parasite transmission
Kinesins are a superfamily of molecular motors that undertake ATP-dependent microtubule-based movement or regulate microtubule dynamics. Plasmodium species, which cause malaria and kill hundreds of thousands annually, encode ~9 kinesins in their genomes. Of these, two – kinesin-8B and kinesin-8X - a...
ORGANISM(S): Plasmodium berghei ANKA 
2022-12-05 | PXD037474 | Pride
Cryo-em Malaria Microtubule Warwick_rtp Atpase Kinesin Motor Flagella 
TranscriptomicsMicroarray analysis identifies the gene signature of surviving motor neurons in human SOD1-related motor neuron disease
Gene expression profiling has been performed previously on motor cortex and spinal cord homogenates and of sporadic ALS cases and controls, to identify genes and pathways differentially expressed in ALS. More recent studies have combined the use of laser capture microdissection (LCM) with gene expre...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-20589 | biostudies-arrayexpress
TranscriptomicsLCM-based microarray analysis of TAU-P301L and SOD1-G93A motor neurons and surrounding glial cells
Familial amyotrophic lateral sclerosis (ALS) represents about 10% of ALS cases. In about 20% of familial ALS patients, a mutation in superoxide dismutase-1 (SOD1) can be found. The ubiquitous SOD1 protein converts superoxide radical anions to oxygen and hydrogen peroxide. Patients with familial ALS ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22482 | biostudies-arrayexpress
ProteomicsStructural Basis of Kinesin-1 Autoinhibition and Its Control of Microtubule-Based Motility
Kinesin-1 is the first identified microtubule-based motor protein that drives anterograde intracellular transport of diverse cargoes in eukaryotic cells. Defects in kinesin-1 activity have been implicated in various human neurological disorders and intracellular pathogens such as bacteria and viruse...
ORGANISM(S): Escherichia coli 
2026-06-03 | PXD073177 | Pride
Kinesin-1 Structure Kinesin Kif5b Plus-end directed Microtubule motor Cryo-em Motor protein 
TranscriptomicsGene expression profiling of resistant and vulnerable motor neuron subtypes in amyotrophic lateral sclerosis
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements. Pathological studies have confirmed that there is relative sparing of the cranial motor nuclei of the oculomotor, trochlear and abducens nerves, although pathological changes resembling those seen i...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-40438 | biostudies-arrayexpress
TranscriptomicsA patient-derived neural stem cell model for hereditary spastic paraplegia
Hereditary Spastic Paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPG4 are a major cause of autosomal-dominant HSP. Spastin, the protein encoded by SPG4, is a microtubule-severing protein and is enriched in the distal axon of cor...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-TABM-1180 | biostudies-arrayexpress
UnknownThe motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
Not available
S-EPMC10130750 | biostudies-literature
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