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TranscriptomicsNon-coding small RNA profiling by high throughput sequencing of bovine primary retinal microvascular endothelial cells
The aim of this study was to identify and quantify microRNAs and other small regulatory RNAs expressed in primary retinal microvascular endothelial cells (RMECs) using deep sequencing. RMECs were isolated, RNA extracted, a small RNA library prepared and deep sequencing performed. A total of 6.8 mill...
ORGANISM(S): Bos taurus 
2012-02-13 | E-GEOD-31340 | biostudies-arrayexpress
TranscriptomicsRNA-seq of brain mural cells and microvascular fragments
Purpose: Pericytes, the mural cells of blood microvessels, have come into focus as regulators of microvascular development and function, but due to paucity of defining markers, the identification and functional characterization of PC remain problematic, and reported data are often controversial. Her...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-75668 | biostudies-arrayexpress
TranscriptomicsWNT Pathway Signalling in Kidney Transplants with Microvascular Injury
Kidney transplant recipients with biopsy-proven microvascular injury (MVI) have increased risk for allograft failure. MVI is often caused by antibody-mediated injury that is resistant to available treatments. Current diagnostic methods are also inadequate, with interobserver variability in tradition...
ORGANISM(S): Homo sapiens 
2019-06-15 | E-GEOD-115989 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of a novel pro-angiogenic small molecule phthalimide neovascular factor 1 (PNF1)
We generated the transcriptional regulatory footprint of phthalimide neovascular factor 1 (PNF1)—a novel synthetic small molecule that exhibits significant in vitro endothelial potency and significant in vivo microvascular network expansion—by performing comparative microarray analysis on PNF1-stimu...
ORGANISM(S): Homo sapiens 
2009-07-17 | E-GEOD-17119 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hypertensive and normotensive rats treated with the AT1 receptor antagonist candesartan and vehicle
In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment ...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2739 | biostudies-arrayexpress
TranscriptomicsComparative genomic profile of human brain microvascular endothelial cells upon TWEAK or TNFα stimulation at 3h, 12h, and 24h
The molecular mechanisms playing a role in TWEAK versus TNFɑ signaling on cerebral microvascular endothelial cells are not well defined. Therefore, we aimed to identify gene expression changes in cultures of human brain microvascular endothelial cells (hCMEC/D3) to address changes initiated by TWEAK...
ORGANISM(S): Homo sapiens 
2022-10-20 | E-MTAB-12222 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dermal microvascular endothelial, fibroblast, and glioblastoma cells treated with mycophenolic acid
The effect of Mycophenolic acid on primary isolated human dermal microvascular endothelial (HDMVEC) and fibroblast cells as well as human glioblastoma brain tumor cell line (U87).
ORGANISM(S): Homo sapiens 
2008-06-25 | E-TABM-315 | biostudies-arrayexpress
TranscriptomicsMultiple waves of transcriptome changes during extended hypoxic induction in human pulmonary microvascular endothelial cells
We profile the expression pattern of human pulmonary microvascular endothelial cells (HPMECs) at different time points of hypoxic stress. Through mRNA-seq, we identify functional waves of minor gene up-regulation at 8 and 24h hypoxia exposure followed by a massive wave of transcriptional activation ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-53510 | biostudies-arrayexpress
TranscriptomicsExpression data from BMP9-treated human dermal microvascular endothelial cells (HMVEC-D)
BMP9 signaling has been implicated in hereditary hemorrhagic telangiectasia and vascular remodeling, acting via the HHT target genes, endoglin and ALK1. This study sought to identify endothelial BMP9-regulated proteins that could affect the HHT phenotype. Gene ontology analysis of cDNA microarray da...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-40960 | biostudies-arrayexpress
UnknownRetinal Microvascular Network and Microcirculation Assessments in High Myopia.
Not available
S-EPMC5253241 | biostudies-literature
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