WNT Pathway Signalling in Kidney Transplants with Microvascular Injury

ABSTRACT: Kidney transplant recipients with biopsy-proven microvascular injury (MVI) have increased risk for allograft failure. MVI is often caused by antibody-mediated injury that is resistant to available treatments. Current diagnostic methods are also inadequate, with interobserver variability in traditional pathology reads, variable assessment of circulating donor-specific antibody between HLA laboratories, and peritubular capillary C4d staining. Molecular assessments of kidney biopsies can provide improved sensitivity for diagnosing MVI and other allograft pathology, while improving reproducibility and objectivity. Most molecular classifiers have been based on whole genome sequencing to develop diagnostic tests, but have provided limited therapeutic targets. In this study, we pursued a candidat

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Seifert 

PROVIDER: E-GEOD-115989 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress