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TranscriptomicsRNA-SEQ of Satb1-knockdown in dopaminergic neurons from the mouse mid-brain
RNA-SEQ profiling of mouse dopaminergic neurons from the mouse mid-brain, with AAV1 injections using a Satb1 shRNA-EGFP construct or a scrambed shRNA-EGFP construct Murine midbrain dopaminergic neurons with Satb1 shRNA treatment or scrambled control
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-70133 | biostudies-arrayexpress
TranscriptomicsKC002-EH005: Genetic and epigenetic features of induced pluripotent stem cell-derived dopaminergic neurons
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro disease modeling and cell replacement therapy for Parkinson’s disease (PD). Both applications crucially require an in-depth profiling of the disease-relevant, iPSC-derived cell type. Midbrain dopaminergic (mDA) neurons derived fr...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-47178 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
Embryonic stem (ES) cells were differentiated in culture to midbrain dopaminergic (mDA) progenitors and subjected to ChIP-seq analysis to resolve genome-wide binding sites of forkhead box protein A2 (Foxa2). Foxa2 was found to directly regulate multiple lineage pathways to specify midbrain dopaminer...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MTAB-1137 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile in embryonic mesencephalon and neuronal primary cultures
In the mammalian central nervous system (CNS) an important contingent of dopaminergic neurons are localized in the substantia nigra and in the ventral tegmental area of the ventral midbrain. They constitute an anatomically and functionally heterogeneous group of cells involved in a variety of regula...
ORGANISM(S): Rattus norvegicus 
2009-05-10 | E-GEOD-15920 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ profiling of mouse whole midbrain and dopaminergic neurons from the mouse mid-brain
RNA-SEQ profiling of mouse whole midbrain and dopaminergic neurons from the mouse mid-brain Murine whole midbrain and murine midbrain dopaminergic neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-64526 | biostudies-arrayexpress
TranscriptomicsExpression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-28365 | biostudies-arrayexpress
ProteomicsProtein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson’s disease in human midbrain dopaminergic neurons
Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with progressive loss of dopaminergic neurons in the substantia nigra, and accumulation of aggregates of α-synuclein. However, the sequence of molecular events that proceed from the SNCA mutation during development, to its...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035500 | Pride
Dopaminergic neurons Proteomics and parkinsons's disease Hipscs Alpha synuclein 
GenomicsChIP-Seq for Pbx1 in the mouse E12.5 ventral midbrain
Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease One sample each for Pbx1, IgG, and input
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82098 | biostudies-arrayexpress
TranscriptomicsDisrupted iron homeostasis causes dopaminergic neurodegeneration in mice
Disruption of local iron homeostasis is a common feature of neurodegenerative diseases. We focused on dopaminergic neurons, asking how iron transport proteins modulate iron homeostasis in vivo. Inactivation of the transmembrane iron exporter ferroportin had no apparent consequences. However, loss of...
ORGANISM(S): Mus musculus 
2015-03-11 | E-GEOD-66730 | biostudies-arrayexpress
Transcriptomicsin-vitro differentiated midbrain dopaminergic neurons from isogenic human induced pluripotent stem cells
We have generated isogenic induced pluripotent stem cell lines by reprogramming human fibroblasts from patients carrying the LRRK2 G2019S mutation with subsequent zinc finger nuclease - mediated targeted correction of the diseased allele. These iPS cell lines were differentiated for 30 days using a ...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-43364 | biostudies-arrayexpress
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