Sort   by:  
 Page size 
TranscriptomicsTranscriptome Profiling of patients with 16p11.2 rearrangements
The 600kb BP4-BP5 16p11.2 CNV (copy number variant) is associated with neuroanatomical, neurocognitive and metabolic disorders. These recurrent rearrangements are associated with reciprocal phenotypes such as obesity and underweight, macro- and microcephaly, as well as autism spectrum disorder (ASD...
ORGANISM(S): Homo sapiens 
2015-05-10 | E-GEOD-57802 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in Williams-Beuren (WBS), Williams-Beuren Region duplication (WBRdupS), Smith-Magenis (DGS), DiGeorge (DGS) lymphoblastoid cell lines
Copy number variants (CNV) influence the expression of genes that map not only within, but also on their flanks. To assess the possible mechanism(s) underlying this “neighboring effect”, we compared intrachromosomal interactions and histone modifications in cell lines of patients affected by genomic...
ORGANISM(S): Homo sapiens 
2013-11-16 | E-GEOD-33784 | biostudies-arrayexpress
TranscriptomicsComparison of age-related changes in gene expression of 2 rat skeletal muscles
In this study we compared Gastrocnemius and Triceps gene expression with age. Our results show that gene expression is massively modulated with age in Gastroc but on the contrary very stable in Triceps, suggesting that Triceps is resistant to age-related defects. 3 groups of age (8 months, 18 months...
ORGANISM(S): Rattus norvegicus 
2016-05-12 | E-GEOD-78702 | biostudies-arrayexpress
TranscriptomicsMouse myoblasts grown on Fibronectin or Collagen I for 72 hours
The goal of this study was to investigate the transcriptional regulation in cells grown on Fibronectin when compared to Collagen I 3 samples per condition
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-81225 | biostudies-arrayexpress
GenomicsGenome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle
To understand the transcriptional basis of circadian rhythms in mouse liver, we generated genome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle. We found that Pol 2 occupancy at promoters and in gene bodies cycle...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35788 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver cells during the circadian cycle at 4 hour time resolution
Cyclic regulatory systems are ubiquitous in cells and tissues. In the liver rhythms in mRNA expression are determined by the homeostatic regulation that operates on daily circumstances. In particular the specific response to nutrients, as well as systemic and peripheral circadian oscillators, contri...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35789 | biostudies-arrayexpress
TranscriptomicsProfiling of mouse muscle stem cells aging and activation upon skeletal muscle injury
Utilizing glycerol intramuscular injections in M. musculus provide a models of skeletal muscle damage followed by skeletal muscle regeneration. In particular, glycerol-induced muscle injury triggers accute activation of skeletal muscle stem cells, called satellite cells. However, aging dramatically ...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-81096 | biostudies-arrayexpress
GenomicsDynamics of SREBP1 binding to DNA in mouse liver
To systematically understand how the circadian clock and the nutrient-driven rhythm integrate to regulate SREBP1 activity, we evaluated genome-wide the binding of SREBP1 to its targets along the day in wild-type (WT) C57BL/6mice. The recruitment of SREBP1 to the DNA showed a highly circadian behavio...
ORGANISM(S): Mus musculus 
2014-03-10 | E-GEOD-48375 | biostudies-arrayexpress
TranscriptomicsMethylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15
Methylation profiles of chr12-16 were generated by meDIP and array hybridisation in 3 cases with maternal uniparental disomy of chromosome 15, and three cases of paternal uniparental disomy of chromosome 15. Comparison of these profiles reveals differentially methylated (imprinted) regions on chromo...
ORGANISM(S): Homo sapiens 
2010-06-12 | E-GEOD-22188 | biostudies-arrayexpress
GenomicsGencord Data Access Committee
Data Access Committee EGAC00001000105
EGAC00001000105 | EGA
Sort   by:  
 Page size