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TranscriptomicsEpigenetic profiling in CD4 and CD8 T cells from Graves’ disease patients reveals changes in genes associated with T cell receptor signaling [methylation]
In Graves’ disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71955 | biostudies-arrayexpress
GenomicsEpigenetic profiling in CD4 and CD8 T cells from Gravesâ?? disease patients reveals changes in genes associated with T cell receptor signaling [ChIP-seq]
In Gravesâ?? disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71952 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling in CD4 and CD8 T cells from Graves’ disease patients reveals changes in genes associated with T cell receptor signaling [gene expression]
In Graves’ disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71956 | biostudies-arrayexpress
TranscriptomicsTranscriptome and Epigenome analysis of fetal and adult liver samples
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-61279 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of fetal and adult liver samples
Genome wide DNA methylation analysis of 96 adult and 14 fetal liver samples The study includes 110 individuals, 14 fetal and 96 adult samples, no replicates. Liver samples from 14 fetuses were obtained at gestational week 8-12. Adult liver samples were collected from 52 organ donors who had met acci...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-61278 | biostudies-arrayexpress
GenomicsOntogeny, distribution and potential roles of hydroxymethylcytosine in human liver function
Background: Interindividual differences in liver functions such as protein synthesis, lipid and carbohydrate metabolism and drug metabolism are influenced by epigenetic factors. The role of the epigenetic machinery in such processes has, however, been barely investigated. 5-hydroxymethylcytosine (5h...
ORGANISM(S): Homo sapiens 
2013-07-29 | E-GEOD-49291 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing Identifies Novel Imprinted Genes in Human Placenta (SNP genotyping)
Fetal health is dependent upon the epigenetic-based regulation of gene expression in placenta. Genomic imprinting is an epigenetic phenomenon common to placenta and refers to the monoallelic expression of a gene in a parental-specific manner. We aimed to detect novel imprinted genes in human placent...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-56685 | biostudies-arrayexpress
TranscriptomicsUsing RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta (RNA-seq)
Given the possible critical importance of placental gene imprinting and random monoallelic expression on fetal and infant health, most of those genes must be identified, in order to understand the risks that the baby might meet during pregnancy and after birth. Therefore, the aim of the current stud...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-56524 | biostudies-arrayexpress
GenomicsDNA methylation and the adverse metabolic outcomes of adiposity
Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...
EGAS00001001922 | EGA
UnknownFamily-GWAS reveals effects of environment and mating on genetic associations.
Not available
S-EPMC12633112 | biostudies-literature
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