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MetabolomicsMild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis

Ambient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains unexplored. Here,&nb...

2026-03-03 | MTBLS13965 | MetaboLights
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012498 | Pride
Post-translational modification Ethcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD or HCD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012437 | Pride
Post-translational modification Ethcd Hcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsMild acid elution and MHC immunoaffinity chromatography reveal similar albeit not identical profiles of the HLA immunopeptidome
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012771 | Pride
Mhc immunoaffinity chromatography Cid Post-translational modification Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
ProteomicsPlasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025937 | JPOST Repository
ProteomicsQuantitative plasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025945 | JPOST Repository
ProteomicsApplicability of chromatographic co-elution for antibiotic research
Identification of the molecular target is crucial for evaluating novel antibiotics. To support target identification, a label-free method based on chromatographic co-elution (TICC) has been developed previously. In TICC, an alteration in the elution profile of the target-bound drug compared to free ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-10-01 | PXD017640 | Pride
Essential proteins Bacillus subtilis Protein complexes Protein-protein interaction 
MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-27 | MSV000098363 | MassIVE
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