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UnknownStructural consequences of cysteinylation of Cu/Zn-superoxide dismutase.
Not available
S-EPMC3859770 | biostudies-literature
UnknownStructural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1.
Not available
S-EPMC8641059 | biostudies-literature
UnknownCysteinylation of a monoclonal antibody leads to its inactivation.
Not available
S-EPMC4966827 | biostudies-literature
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD or HCD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012437 | Pride
Post-translational modification Ethcd Hcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012498 | Pride
Post-translational modification Ethcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsCysteinylation of peroxiredoxin 2 upon incubation with BODIPY® FL L-Cystine
It has remained unknown how cells reduce cystine taken up from the extracellular space, which is a required step for further utilization of cysteine in key processes such as protein or glutathione synthesis. Here we show that the thioredoxin-related protein of 14 kDa (TRP14, encoded by TXNDC17) is t...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD050368 | Pride
Cysteinylated proteins 
ProteomicsTRP14 is the rate limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. 42 proteins showed higher cysteinylation levels in TRP14 knockdown cells compared to wild-type cells upon biotinylated cysteine incubation and subsequent streptavidin pulldown. Figure 2C.
It has remained unknown how cells reduce cystine taken up from the extracellular space, which is a required step for further utilization of cysteine in key processes such as protein or glutathione synthesis. Here we show that the thioredoxin-related protein of 14 kDa (TRP14, encoded by TXNDC17) is t...
ORGANISM(S): Homo sapiens (Human) 
2024-06-05 | PXD038965 | Pride
Thioredoxin Pancreatitis Cysteinylation Bodipy 
ProteomicsMild acid elution and MHC immunoaffinity chromatography reveal similar albeit not identical profiles of the HLA immunopeptidome
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012771 | Pride
Mhc immunoaffinity chromatography Cid Post-translational modification Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
UnknownTRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Not available
S-EPMC11217419 | biostudies-literature
UnknownEngineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression.
Not available
S-EPMC3893235 | biostudies-literature
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