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ProteomicsAntibody-independent identification of bovine milk-derived peptides in breast-milk
Exclusively breast-fed infants can exhibit clear signs of IgE or non IgE-mediated cow’s milk allergy. The definite characterization of dietary cow’s milk proteins (CMP) that survive the maternal digestive tract to be absorbed into the bloodstream and secreted into breast milk remains missing. The ai...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-02 | MSV000080880 | MassIVE
ProteomicsAntibody-independent identification of bovine milk-derived peptides in breast-milk
Exclusively breast-fed infants can exhibit clear signs of IgE or non IgE-mediated cow’s milk allergy. The definite characterization of dietary cow’s milk proteins (CMP) that survive the maternal digestive tract to be absorbed into the bloodstream and secreted into breast milk remains missing. The ai...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD003657 | Pride
Bovine Peptides Human Milk Lc-ms/ms 
ProteomicsEndegenous human milk peptides
Variations in endogenous peptide profiles, functionality, and the enzymes responsible for the formation of these peptides in human milk are understudied. Additionally, there is a lack of knowledge regarding peptides in donor human milk, which is used to feed preterm infants when mother’s own milk is...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD007967 | Pride
Human milk Peptides Endegenous 
ProteomicsPeptidomics analysis of milk protein-derived peptides released over time in the preterm infant stomach
Over the course of milk digestion, native milk proteases and infant digestive proteases fragment intact proteins into peptides with potential bioactivity. This study investigated the release of peptides over three hours of gastric digestion in 14 preterm infant sample sets. The peptide content was e...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2019-03-12 | PXD012192 | Pride
Gastric Human milk Preterm Digestion Peptide Bioactive 
ProteomicsPersonalized Human Milk Profiling
Human milk is the truest form of personalized nutrition, supporting dynamic needs of the infant with important nutritional and bioactive constituents that change throughout lactation. Additionally, human milk is individual specific and is unique for each mother-infant dyad. Proteins and endogenous p...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD014917 | Pride
Human milk Immunity Endogenous peptides Personalized nutrition Proteins 
ProteomicsHuman milk and gastric peptidomics
It is unclear to what degree protein degradation occurs in the infant stomach and whether peptides previously annotated for bioactivity are released. This study combined nanospray liquid chromatography separation with time of flight mass spectrometry, comprehensive structural libraries and informati...
ORGANISM(S): Homo sapiens (Human) 
2014-04-15 | PXD000688 | Pride
Peptidomics Human milk 
ProteomicsAllergen Shedding in Human Milk from Mothers of Preterm Infants: Proteomic and Peptidomic Feasibility and Pilot Analysis
There is little information regarding the allergen content of milk feeds in the preterm population. Previous studies have evaluated specific proteins/peptides via ELISA, but no studies have performed a broad analysis of the allergenic peptide content and protease activity of milk feeds in this popul...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-01-26 | PXD033473 | Pride
Human Allergen Native paptides Milk 
ProteomicsHeat-treatments affect protease activities and peptide profiles of ruminants’ milk
Proteases present in milk are heat-sensitive, and their activities increase or decrease depending on the intensity of the thermal treatment applied. The thermal effects on the protease activity are well-known for bovine milk but poorly understood for ovine and caprine milk. This study aimed to deter...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD022702 | Pride
Peptidomics Milk 
ProteomicsPreterm birth increases endogenous human milk peptide release compared to term birth
Hundreds of naturally occurring milk peptides have been found in term human milk. Whether there are differences between the levels of these peptides between term and preterm milk remains unknown. Premature milk is produced before complete maturation of the mammary gland and is under the influence of...
ORGANISM(S): Homo sapiens (Human) 
2016-07-07 | PXD001079 | Pride
Peptidomics Human milk 
ProteomicsDiscovery and quantification of non-human proteins in human milk
The question whether and which non-human peptides or proteins are present in human milk was raised many decades ago. However, due to cross-reactivity or nonspecific antibody recognition, the accuracy of detection by immunochemical methods has been a concern. Additionally, the relative low-abundance ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Felis catus (Cat) (Felis silvestris catus) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) Oryza sativa (Rice) Equus caballus (Horse) 
2018-12-04 | PXD011599 | Pride
Non-human peptides Shotgun proteomics Human milk Mass spectrometry Non-human proteins Parallel reaction monitoring 
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