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TranscriptomicsMicroarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies
Mutations in BRCA1 and BRCA2 genes confer an increased lifetime risk for breast and ovarian cancer. Ovarian cancer risk can be decreased by risk-reducing salpingo-oophorectomy (RRSO). Studies on RRSO material have altered the paradigm of serous ovarian cancer pathogenesis. The purpose of this study ...
ORGANISM(S): Homo sapiens 
2015-02-28 | E-GEOD-66387 | biostudies-arrayexpress
ProteomicsMicroprotein discovery in HEK293T and K562 cells
The objective of this project is to identify novel microproteins in HEK293T and K562 cell lysates with subsequent fractionation, for the purpose of identifying predicted microproteins from the tool ShortStop.
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD050875 | Pride
Microprotein Lc ms/ms 
TranscriptomicsPathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis
Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Although both activities are catalyzed on a single active site, the...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44311 | biostudies-arrayexpress
TranscriptomicsAdaption of Dinoroseobacter shibae to anaerobic conditions
To unravel the adaptation strategies of D. shibae to anaerobic conditions in microaerobic to anaerobic parts of the ocean and to define the underlying regulatory network an anaerobic shift experiment in Salt-Water-Medium in a chemostate was established. Transcriptome analyses were used to investigat...
ORGANISM(S): Dinoroseobacter shibae 
2013-08-30 | E-GEOD-47445 | biostudies-arrayexpress
TranscriptomicsAnchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the medaka
This study assessed the implications of a 14 day sub-chronic exposure of ethinylestradiol (EE2; 1.0 or 10.0 M-BM-5g/L EE2) on male medaka fertility, testicular histology and testicular gene expression. The findings demonstrate that a 14 day exposure to EE2 induced impaired male reproductive capacity...
ORGANISM(S): Oryzias latipes 
2013-03-06 | E-GEOD-44859 | biostudies-arrayexpress
MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
UnknownAssociation of Thoracic Aortic Aneurysm Size With Long-term Patient Outcomes: The KP-TAA Study.
Not available
S-EPMC9535537 | biostudies-literature
TranscriptomicsAnalysis of Pseudomonas aeruginosa evolving in the cystic fibrosis lung uncovers limited evidence that mutator lineages are more genetically variable than non-mutator lineages
Pseudomonas aeruginosa evolving in the cystic fibrosis (CF) lung encounters selection via iron-limitation, antibiotics, immune system effectors and other microbes. Standing genetic variation, which depends on rates of horizontal gene transfer (HGT) and mutation supply, controls response to challenge...
ORGANISM(S): Pseudomonas aeruginosa 
2011-10-31 | E-GEOD-25481 | biostudies-arrayexpress
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
TranscriptomicsHistologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients
Gene expression in histologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients share a similar profile Introduction: We hypothesized that gene expression in histologically normal epithelium (NlEpi) would differ in breast cancer patients (HN) compared...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20437 | biostudies-arrayexpress
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