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ProteomicsRegulation of the ER stress response by a mitochondrial microprotein
Cellular homeostasis relies on having dedicated and coordinated responses to a variety of stresses. The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a common stress that triggers a conserved pathway called the unfolded protein response (UPR) that mitigates damage, and dysre...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014890 | Pride
Mitochondrial Smorfs Microprotein Er stress response 
GenomicsMicroprotein knockout in rescue cell lines and control conditions
Microprotein knockout in rescue cell lines and control conditions
PRJNA971880 | ENA
GenomicsLncRNA ASH1L-AS1 Encodes the Microprotein APPLE to Drive HCC Tumorigenesis
LncRNA ASH1L-AS1 Encodes the Microprotein APPLE to Drive HCC Tumorigenesis
PRJNA1249402 | ENA
ProteomicsPooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response
Microproteins encoded by short open reading frames (sORFs) of less than 100 codons have been predicted to constitute a substantial fraction of the eukaryotic proteome. However, relevance and roles of the majority of microproteins remain undefined because only a small fraction of these intriguing cel...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD057806 | Pride
Microprotein 
UnknownThe ERVK3-1 Microprotein Interacts with the HUSH Complex.
Not available
S-EPMC12339190 | biostudies-literature
ProteomicsThe ERVK3-1 microprotein interacts with the HUSH complex
Human endogenous retroviruses (hERVs) are molecular remnants of ancient retroviruses that integrated into the human germline and now make up 8% of the human genome. The human ERVK3-1 locus was recently annotated as encoding a 109-amino acid microprotein homologous to a retroviral Rec domain. ERVK3-1...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD064459 | Pride
Hervs Proximity labelling Lc-msms 
UnknownMIEF1 Microprotein Regulates Mitochondrial Translation.
Not available
S-EPMC6443411 | biostudies-literature
ProteomicsMAVI1, an Endoplasmic Reticulum-localized Microprotein, Suppresses Antiviral Innate Immune Response by Targeting MAVS on Mitochondrion
Pattern recognition receptors (PRRs)-mediated innate immune responses are critical for host defense against microbial pathogens including RNA/DNA viruses. A growing number of coding genes and genes originally defined as non-coding RNAs (ncRNAs) are found to encode short peptides or proteins, named m...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039375 |
UnknownIdentification of Microprotein-Protein Interactions via APEX Tagging.
Not available
S-EPMC5499098 | biostudies-literature
GenomicshnRNPA is a novel regulator of a mitochondrial microprotein expression
hnRNPA is a novel regulator of a mitochondrial microprotein expression
PRJNA716170 | ENA
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