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GenomicsGenetic Analysis of Limb Malformation Disorders: Miller Syndrome Sequencing Study (LMD-MS)

The overall goal of this project is to investigate the etiology and pathogenesis of malformations (i.e., birth defects) of the limb, concentrating on abnormalities of limb patterning such as limb deficiency/duplications and multiple congenital contractures.

The exome sequences of two s...

phs000244.v1.p1 | EGA
TranscriptomicsExpression data from OT-I CD8 T cells activated with DC in the presence or absence of CpG-Induced Inflammation
Inflammatory cytokines promote the accumulation of activated CD8 T cells. Here, we transfer 600 OT-I CD8 T cells iv into naïve C57BL/6 hosts. One day later, 500,000 LPS-matured and OVA257 peptide-coated DC were injected iv into OT-I CD8 T cell seeded hosts with (DC+CpG) or without (DC). Other se...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53200 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BE(2)-C neuronal responses to type I IFN stimulation
Human neuronal differentiation alters responsiveness to innate immune stimuli and virus infections. We used microarrays to examine the transcriptional responses of the human BE(2)-C neuroblastoma cell line to retinoic acid-induced differentiation and type I IFN stimulation. Experiment Overall Design...
ORGANISM(S): Homo sapiens 
2009-07-12 | E-GEOD-16450 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of fetal lung and cultured fetal lung derived organoids with pluripotent stem cell derived lung organoids
Underdeveloped lungs are the primary cause of death in premature infants, however, little is known about stem and progenitor cell maintenance during human lung development. In this study, we have identified that FGF7, Retinoic Acid and CHIR-99021, a small molecule that inhibits GSK3 to activate Wnt ...
ORGANISM(S): Homo sapiens 
2018-11-17 | E-MTAB-6023 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans specific cells from the nervous system.
Background: With its fully sequenced genome and simple, well-defined nervous system, the nematode C. elegans offers a unique opportunity to correlate gene expression with neuronal differentiation. The lineal origin, cellular morphology and synaptic connectivity of each of the 302 neurons are known....
ORGANISM(S): Caenorhabditis elegans 
2008-06-15 | E-GEOD-8004 | biostudies-arrayexpress
UnknownLoss and Gain of Group I Introns in the Mitochondrial Cox1 Gene of the Scleractinia (Cnidaria; Anthozoa).
Not available
S-EPMC6517707 | biostudies-literature
MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
UnknownQuality of Life During Treatment With Chemohormonal Therapy: Analysis of E3805 Chemohormonal Androgen Ablation Randomized Trial in Prostate Cancer.
Not available
S-EPMC5891128 | biostudies-literature
TranscriptomicsTranscription profiling of human BE(2)-C neuronal responses to type I IFN stimulation and WEEV infection
This SuperSeries is composed of the following subset Series:; GSE16450: Human BE(2)-C neuronal responses to type I IFN stimulation; GSE16451: Human BE(2)-C neuronal responses to WEEV infection Experiment Overall Design: Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-07-12 | E-GEOD-16452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans embryonic muscle
Background: The force generating mechanism of muscle is evolutionarily ancient; the fundamental structural and functional components of the sarcomere are common to motile animals throughout phylogeny. Recent evidence suggests that the transcription factors that regulate muscle development are also ...
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | E-GEOD-8462 | biostudies-arrayexpress
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