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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownEffect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: a randomized, double-blind, placebo-controlled trial.
Not available
S-EPMC4979167 | biostudies-literature
TranscriptomicsRNA-seq from heart tissue of 192 heterogeneous stock rats
We measured heart gene expression in 192 heterogeneous stock rats. These animals were part of a larger cohort that were extensively phenotyped and genotyped and originally published in PMID: 23708188, although the gene expression data here were not included in that study.
ORGANISM(S): Rattus norvegicus 
2023-04-03 | E-MTAB-12701 | biostudies-arrayexpress
ProteomicsRNA-binding proteins associating with the 3’UTR of the ATP6V1A transcript in SIRT1 knock-down cells
Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds various RNA transcripts and functions as a tumor promoter, although little is known regarding the mechanisms that regulate its roles in RNA metabolism (1-3). Here we find that IGF2BP2 binds to the 3’ untranslated region of the tran...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028114 | Pride
Breast cancer Sirt1 Rna-binding proteins Human Atp6v1a 
ProteomicsThe interactome of Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds various RNA transcripts and functions as a tumor promoter, although little is known regarding the mechanisms that regulate its roles in RNA metabolism (1-3). Here we find that IGF2BP2 binds to the 3’ untranslated region of the tran...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028084 | Pride
Sirt1 Igf2bp2 Protein-protein interactions 
Transcriptomicspamknight ovine abomasum1
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of Teladorsagia circumcincta infection.
ORGANISM(S): Ovis aries 
2011-05-20 | E-TABM-1149 | biostudies-arrayexpress
Transcriptomicspamknight ovine abomasum
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of T. circumcincta infection.
ORGANISM(S): Ovis aries 
2011-05-20 | E-TABM-1150 | biostudies-arrayexpress
GenomicsSequencing and analysis of a South Asian-Indian personal genome
India with over 1.3 billion people is estimated to carry three times more genetic diversity compared to Europe. Next-generation sequencing technologies have facilitated the understanding of diversity by enabling whole genome sequencing at greater speed and lower cost. While multiple genomes from p...
EGAS00001000328 | EGA
GenomicsEstrogen Receptor Positive Breast Cancer: Aromatase Inhibitor Response Study

Highly variable outcomes are observed in patients with estrogen receptor positive (ER+) breast cancer who undergo preoperative estrogen deprivation therapy with aromatase inhibitors (AI). In this study, 46 tumor and normal genomes and 31 exomes of participants selected from two clinical trials of...

phs000472.v1.p1 | EGA
UnknownDesign and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial.
Not available
S-EPMC6888890 | biostudies-literature
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