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ProteomicsAnalysis of protein regulation in cucumber leaves after Corynespora cassiicola inoculation: a proteomic approach
Corynespora leaf spot (CSL), caused by Corynespora cassiicola, has become one of the most important foliar diseases of cultivated cucumber. However, the defense mechanisms of cucumber plants in response to C. cassiicola are still poorly understood. Here, proteins from resistant plants were analyzed ...
ORGANISM(S): Cucumis sativus 
2019-09-26 | PXD012903 | Pride
Corynespora cassiicola Histochemical staining Defense-related proteins Cucumber Itraq Qrt-pcr 
ProteomicsLiP-small molecule mapping of Farrerol
Limited proteolysis combined with mass spectrometry of farrerol treated. Briefly, cell lysates containing approximately 500 μg of total protein sample were incubated with farrerol or vehicle (DMSO) for 10 min at 25 °C. Proteinase K (5 μg, Sigma–Aldrich) was added simultaneously to each sample for t...
ORGANISM(S): Homo Sapiens 
2022-08-25 | PXD036308 |
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
MetabolomicsGeneration of a chromosome-scale genome assembly of the insect-repellent terpenoid-producing Lamiaceae species, Callicarpa americana

BACKGROUND: Plants exhibit wide chemical diversity due to the production of specialized metabolites that function as pollinator attractants, defensive compounds, and signaling molecules. Lamiaceae (mints) are known for their chemodiversity and have been cultivated for use as culi...

2020-12-04 | MTBLS1983 | MetaboLights
MetabolomicsUntargeted metabolomics reveals metabolic mechanism of degrading chicken feathers by Acrophialophora levis

Chicken feathers constitute a major waste in poultry processing due to their resistance to degradation. Microbial degradation offers a promising solution for enhancing the utilization of feather waste. However, the metabolic mechanisms underlying microbial feather degradation remain poorly unders...

2025-11-19 | MTBLS13331 | MetaboLights
ProteomicsRapid expansion of primary human vocal fold epithelial cells via targeted pathway inhibition and anchorage-independent sphere culture
Vocal fold epithelial cells (VFE) serve critical physiologic and immunologic functions at the boundary between the upper and lower airways but are difficult to maintain and expand in primary culture. This technical challenge has impeded progress in VFE biology as well as cell banking for translation...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD064066 | Pride
ProteomicsExploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell co-culture system
A global exploration of the complex interplay between protein conformational changes and phosphorylation events in cell-cell interactions is crucial for understanding the dynamic nature of protein modifications. This understanding is essential for developing novel targeted therapies for pancreatic c...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD059270 | Pride
ProteomicsIncreased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation
Neurons heavily depend on the ability of the secretory pathway to deliver correctly folded polypeptides to the periphery of the cell for the assembly, maintenance, and normal functioning of synapses. The endoplasmic reticulum (ER) acetylation machinery has emerged as a novel branch of the more gener...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-31 | PXD051786 | Pride
Lysine acetylation Autism spectrum disease Atase1 Atase2 
ProteomicsA clinic responder-derived defined microbial consortium enhances anti-PD-1 immunotherapy efficacy in mice
Growing evidence supports the gut microbiota as a promising target for enhancing the efficacy of cancer immunotherapy. However, the success of microbiota-targeting interventions has been limited, partly due to interindividual microbial heterogeneity. Here, we designed and constructed a defined cons...
ORGANISM(S): Firmicutes bacterium HGW-Firmicutes-5 
2026-01-14 | PXD064618 | Pride
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
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