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This study presents untargeted LC–MS/MS metabolomics and lipidomics datasets comparing CON and MAL experimental groups acquired in both positive and negative electrospray ionization modes. For quality control, a pooled QC sample was prepared by mixing equal volumes of all study samples and was an...

2026-01-20 | MTBLS13731 | MetaboLights
Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential Eur J Med Chem. 2023 Feb 5;247:115035. doi: 10.1016/j.ejmech.2022.115035. Epub 2022 Dec 22. Slavish, ...
ORGANISM(S): Influenza Virus A/california/04/2009 
2023-07-06 | MSV000092363 | MassIVE
In this study, a Cre-loxP system was used to generate eIF3a conditional knockout mice. Tandem mass tag (TMT) labeling with LC-MS/MS analysis was used to identify differentially expressed proteins (DEPs) in fat, lungs, skin, and spleen tissue of the eIF3a knockout mice and controls. Bioinformatics an...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD041416 | Pride
Patient-derived GBM stem-like cells (GSCs) were first cultured to form glioma spheroids and then co-cultured with the brain organoid (BO) derived from fetal rat brains for 72 hours. To investigate the metabolite produced by GBM under physiological conditions, , we used an in vitro co-culture model f...
2026-04-15 | MTBLS14187 | MetaboLights
We use ChIP-Seq technology to profile the occupancy of histone H2A.Z and its chaperone in HeLa cells genome wide to check if they are co-colocalized. H2A.Z is ChIPed by antibody and its chaperone is tagged by Flag and ChIPed by M2 beads against Flag. ChIPed fragments are sequenced by Illumina HiSeq ...
ORGANISM(S): Homo sapiens 
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