Sort   by:  
 Page size 
ProteomicsRole of Mincle overexpression in pneumococcal pneumonia
Macrophage-inducible C-type lectin (Mincle) dependent sensing of pathogens trig-gers proinflammatory immune responses in professional phagocytes that contribute to protect the host against pathogen invasion. Here, we examined whether overex-pression of Mincle designed to improve early pathogen sensi...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-05 | PXD018752 | Pride
Innate immunity Lung Mincle S. pneumoniae Nlrp3 Glc-dag 
ProteomicsCombined phosphoproteome analysis of the response to mycobacterial cord factor reveals a dichotomy of Mincle-dependent and -independent signaling in macrophages
Sensing of Mycobacterium tuberculosis by the immune system relies on recognition by macrophages. Mycobacterial cord factor, trehalose-6,6’-dimycolate (TDM), is the most abundant cell wall glycolipid and binds to the C-type lectin receptor Mincle. To explore the kinase signaling linking the TDM-Mincl...
ORGANISM(S): Mus musculus (Mouse) Mycobacterium tuberculosis 
2019-01-17 | PXD009513 | Pride
Macrophages Mycobacterium tuberculosis Mouse Phosphoprotoemic Dimethyl 
TranscriptomicsExpression data from peritoneal macrophages stimulated with trehalose-6,6'-dimycolate (TDM)
Macrophage-inducible C-type lectin (Mincle, Clec4e) is a pathogen sensor that recognizes pathogenic fungi and Mycobactrium tuberculosis. We perfomed microarray analysis using peritoneal macrophages stimulated with TDM, a mycobacterial cell wall glycolipid that is known to be a Mincle ligand. Many ch...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52338 | biostudies-arrayexpress
GenomicsSingle-cell sequencing reveals Mincle receptor mediated inflammation for resolution in ischemic kidney injury
Single-cell sequencing reveals Mincle receptor mediated inflammation for resolution in ischemic kidney injury
PRJNA1110735 | ENA
UnknownMouse mincle: characterization as a model for human mincle and evolutionary implications.
Not available
S-EPMC4533885 | biostudies-literature
TranscriptomicsTranscriptional and translational analysis of wild-type and Mincle-KO macrophages
Analysis of total RNAs from wild-type and Mincle-KO macrophages stimulated with TLR2 ligand and co-stimulated with TLR2 ligand and Mincle ligand. And analysis of total and polysomal RNAs from wild-type macrophages co-stimulated with TLR2 ligand and Mincle ligand in the presence or absence of DHS inh...
ORGANISM(S): Mus musculus 
2016-07-10 | GSE70793 | GEO
UnknownMincle Signaling Promotes Con A Hepatitis.
Not available
S-EPMC5026929 | biostudies-literature
TranscriptomicsSingle-cell sequencing reveals Mincle receptor mediated inflammation for resolution in ischemic kidney injury
Recent studies have demonstrated a strong association between acute kidney injury (AKI) and chronic kidney disease (CKD), while the unresolved inflammation is believed to be a driving force for this chronic transition process. As a transmembrane pattern recognition receptor, Mincle (macrophage-induc...
ORGANISM(S): Mus musculus 
2024-05-23 | GSE267242 | GEO
UnknownMincle suppresses Toll-like receptor 4 activation.
Not available
S-EPMC6608084 | biostudies-literature
TranscriptomicsThe role of Clec4e (Mincle) in microglia response to transient ischemic injury
This data set shows dramatic changes in gene expression in microglia isolated from C57Bl6/J mice subjected to transient middle cerebral artery occlusion, as compared to those subjected to sham surgery. Mice deficient in Mincle (Clec4e-/-) showed significantly improved injury outcomes 3 and 7 days af...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-77986 | biostudies-arrayexpress
Sort   by:  
 Page size