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ProteomicsDyrk1a P21 phosphoprotoemic data
Dyrk1A deficiency is linked to various neurodevelopmental disorders, including developmental delays and autism spectrum disorders (ASD). Haploinsufficiency of Dyrk1a in mice leads to ASD-related phenotypes, although key pathological mechanisms remain unclear. In addition, human DYRK1A mutations have...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-04 | PXD050102 | Pride
Dyrk1a Asd Phosphorylation Lc-ms/ms 
ProteomicsQuantitative phosphoprotoemic analysis of cold induced signaling in jurkat cells
We have performed quantitative phosphoproteomic analysis on jurkat cells. Phosphorylation change was compared between jurkat cells incubated on ice and those incubated in 37 degree water bath. And the combination of cold induced and OKT3/4 antibody induced signaling was compared.
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD001105 | Pride
Cold induced Phosphorylated Jurkat Label free 
ProteomicsCombined phosphoproteome analysis of the response to mycobacterial cord factor reveals a dichotomy of Mincle-dependent and -independent signaling in macrophages
Sensing of Mycobacterium tuberculosis by the immune system relies on recognition by macrophages. Mycobacterial cord factor, trehalose-6,6’-dimycolate (TDM), is the most abundant cell wall glycolipid and binds to the C-type lectin receptor Mincle. To explore the kinase signaling linking the TDM-Mincl...
ORGANISM(S): Mus musculus (Mouse) Mycobacterium tuberculosis 
2019-01-17 | PXD009513 | Pride
Macrophages Mycobacterium tuberculosis Mouse Phosphoprotoemic Dimethyl 
ProteomicsPhosphoproteomic analysis identifies supervillin as a new ERK3 substrate regulating cytokinesis and ploidy of breast cancer cells
Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD028061 | Pride
Breast cancer Cytokinesis Supervillin Erk3 Ploidy Phosphoprotoemic 
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