Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse neurobastoma N18 cell line transfected with a pAd-Dyrk1a vector
The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located ...
ORGANISM(S): Mus musculus 
2009-02-27 | E-GEOD-14030 | biostudies-arrayexpress
ProteomicsA proteomics-based interaction screen links DYRK1A to RNF169 and to the DNA damage response
DYRK1A is a protein kinase whose dysregulation is linked to disease in humans. On the one side, its overexpression in trisomy 21 has been linked to certain Down syndrome pathological traits, while inactivating mutations in just one allele that hinders its function are responsible for a rare clinical...
ORGANISM(S): Homo sapiens (Human) 
2019-07-15 | PXD011925 | Pride
Dyrk1a Rnf169 Dna damage Interactome Lcmsms 
GenomicsChromatin-wide profiling of the protein kinase DYRK1A reveals a role as a transcriptional activator of cell growth related genes
DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of mammalian cells, although its nuclear function remains unclear. Genome-wide ana...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-63712 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 telencephalon from 152F7 transgenic mouse and neuroblastoma N18 cell line tranfected with a pAd-Dyrk1a vector
This SuperSeries is composed of the following subset Series:; GSE14021: Transcriptional analysis of E12.5 telencephalon from 152F7 transgenic mouse; GSE14030: Transcriptional analysis of murine neurobastoma N18 cell line transfected with a pAd-Dyrk1a vector Experiment Overall Design: Refer to indivi...
ORGANISM(S): Mus musculus 
2009-02-27 | E-GEOD-14105 | biostudies-arrayexpress
Transcriptomicsdyrk1a
Transcription profiling of transgenic down syndrome mouse model to show the role of DYRK1A gene. The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse m...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14072 | biostudies-arrayexpress
ProteomicsNuclear F-actin Assembly on Damaged Chromatin is Regulated By DYRK1A and Spir1 Phosphorylation
The uploaded data are described within "DYRK1A promotes nuclear F-actin assembly to effect DSB repair metabolism". Peptides from RPE1 epithelial cells with either, over expression of DYRK1A, normal expression of DYRK1A, or knockout of DYRK1A were labeled with TMTpro-16 reagents and phosphopeptides e...
ORGANISM(S): Homo sapiens (Human) 
2024-07-19 | PXD031714 | Pride
Dyrk1a  dsb repair  spir1  dsb mobility  actin dynamics 
ProteomicsDyrk1a P60 phosphoproteomic data
Dyrk1A deficiency is linked to various neurodevelopmental disorders, including developmental delays and autism spectrum disorders (ASD). Haploinsufficiency of Dyrk1a in mice leads to ASD-related phenotypes, although key pathological mechanisms remain unclear. In addition, human DYRK1A mutations have...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-04 | PXD050100 | Pride
Dyrk1a Autism Phosphorylation Asd Lc-ms/ms 
GenomicsExpression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice
Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice
PRJNA525078 | ENA
GenomicsRole of DYRK1A in MPN
Role of DYRK1A in MPN
PRJNA947965 | ENA
ProteomicsGlobal Phosphoproteomics of DYRK1A Inhibition in Glioblastoma Cells
Here we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma, using both pharmacological and genetic tools combined with global phosphoproteomics. Our data show that DYRK1A inhibitors affect a much broader proportion of the phosphoproteome than DYRK1A knockdown. By over...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD020441 | Pride
Glioblastoma Proteomics U251 Dyrk1a Phosphoproteome Post-translational modification Mass spectrometry Signal transduction Phosphorylation Cancer Phosphoproteomics 
Sort   by:  
 Page size