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Wolbachia pipientis is a ubiquitous intracellular bacterium that is known for its manipulation of reproduction in arthropod hosts. Wolbachia has also been shown to colonize virtually all somatic tissues, including the brain, but little is known about the interaction between host and bacterium in the...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-10 | PXD055815 | Pride
Purpose: Treatment of acute promyelocytic leukemia (APL) with the retinoid, all trans retinoic acid (ATRA), along with standard chemotherapy has significantly improved survival compared to chemotherapy alone1. ATRA mediates its benefit in APL by overcoming the transcriptional block mediated by PML-R...
ORGANISM(S): Homo sapiens 
Here, we introduce a reversible protein tag, ProMTag, that enables whole proteome capture, cleanup, and release of intact proteins for top-down analysis. Alternatively, the addition of a novel Trypsin derivative to the workflow generates peptides for bottom-up analysis. We show that the ProMTag work...
ORGANISM(S): Burkholderia sp. 2332 Saccharomyces cerevisiae (Baker's yeast) Gallus gallus (Chicken) 
2022-02-14 | PXD027799 | Pride
Typical multiomics studies employ separate methods for DNA, RNA, and protein sample preparation, which is labor intensive, costly, and prone to sampling bias. We describe here a method for preparing high-quality DNA, RNA, and protein or peptides for whole genome sequencing, RNA sequencing, and whole...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-29 | MSV000092780 | MassIVE
Immunoprecipitation is among the most widely utilized methods in biomedical research, with applications that include the identification of antibody targets and associated proteins. The path to identifying these targets is not straightforward, however, and often requires the use of chemical crosslink...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056617 | Pride
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