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MetabolomicsMetabolic analysis of wound response in Wolbachia infected Drosophila melanogaster

Viral studies of Drosophila melanogaster typically involve virus injection with a small needle, causing post-injury a wounding/wound healing response, in addition to the effects of viral infection. However, the metabolic response to the needle injury is understudied, and many viral investigations...

2025-11-18 | MTBLS13248 | MetaboLights
MetabolomicsWolbachia modulation of lipid metabolism in Aedes albopictus mosquito cells
Certain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue by Aedes mosquitoes, and the mechanisms responsible are still not well understood. Direct infusion and liquid chromatography FT-ICR mass spectrometry based lipidomicse...
MTBLS210 | MetaboLights
TranscriptomicsWolbachia mCGH of Five Supergroup A Strains
Using microarray-based comparative genome hybridizations (mCGH), the genomic content of Wolbachia pipientis wMel from Drosophila melanogaster was compared to the Wolbachia from D. innubila (wInn), D. santomea (wSan), and three strains from D. simulans (wAu, wRi, wSim). Cy3- and Cy5-labeled probes w...
ORGANISM(S): Wolbachia pipientis 
2010-06-25 | E-GEOD-13825 | biostudies-arrayexpress
ProteomicsComprehensive quantitative proteome analysis of Aedes aegypti to interrogate Wolbachia pipientis and Zika virus interference phenomenon
Zika virus is a global public health emergency due to its association with microcephaly, Guillain-Barré syndrome, neuropathy, and myelitis in children and adults. A total of 87 countries have had evidence of autochthonous mosquito-borne transmission of Zika virus, distributed across four continents...
ORGANISM(S): Aedes aegypti 
2021-02-26 | PXD022665 | Pride
Head Wolbachia Zikv Aedes aegypti 
TranscriptomicsWolbachia infection modifies the profile, shuttling and structure of microRNAs in a mosquito cell line
We characterized the miRNA composition of the nucleus and the cytoplasm of uninfected cells and compared it with the one of cells infected with the endosymbiotic bacterium Wolbachia strain wMelPop-CLA. We found an overall increase of small RNAs between 18 and 28 nucleotides in both cellular compartm...
ORGANISM(S): Aedes aegypti 
2014-02-22 | E-GEOD-55210 | biostudies-arrayexpress
ProteomicsInterspecies isobaric labeling-based proteomics reveals protein changes in the ovary of Aedes aegypti co-infected with ZIKV and Wolbachia
Zika is a vector-borne disease caused by an arbovirus (ZIKV) and overwhelmingly transmitted by Ae. aegypti. This disease is linked to adverse fetal outcomes, mostly microcephaly in newborns, and other clinical aspects such as acute febrile illness and neurologic complications, for example Guillain-B...
ORGANISM(S): Aedes aegypti 
2022-08-12 | PXD031728 | Pride
Proteome  quantitative  aedes aegypti  wolbachia  zika virus  juvenile hormone  immune defense. 
TranscriptomicsTranscription profiling by array of Aedes aegypti infected with Wolbachia strains wMelPop and wMel
Wolbachia is a vertically transmitted intracellular bacteria that infect most than 60% of insect species. The strains wMelPop and wMel were introduced in the dengue virus vector Aedes aegypti, naturally not infected by Wolbachia. Recently, it was shown that those two strains inhibit dengue virus rep...
ORGANISM(S): Aedes aegypti 
2012-01-01 | E-MEXP-2931 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Wolbachia infected Anopheles gambiae Sua5B cells
Wolbachia, an endosymbiotic bacterium, is being investigated as a vector control agent in several insect species. Along with the well known classical reproductive parasitism Wolbachia employs against its host to spread within the population, it is emerging that the bacteria can protect the host agai...
ORGANISM(S): Anopheles gambiae 
2011-03-02 | E-GEOD-23215 | biostudies-arrayexpress
ModelsNdii2015-transmission dynamics of dengue in the presence of Wolbachia.
Use of the bacterium Wolbachia is an innovative new strategy designed to break the cycle of dengue transmission. There are two main mechanisms by which Wolbachia could achieve this: by reducing the level of dengue virus in the mosquito and/or by shortening the host mosquito's lifespan. However, alth...
2020-03-20 | MODEL2003160002 | BioModels
ProteomicsWolbachia strains differ in arbovirus inhibition mechanisms in Aedes mosquitoes
Some strains of the inherited bacterium Wolbachia have been shown to be effective at reducing the transmission of dengue and other positive-sense RNA viruses by Aedes aegypti in both laboratory and field settings and are being deployed for dengue control. The degree of virus inhibition varies betwee...
ORGANISM(S): Aedes Aegypti (ncbitaxon:7159) Wolbachia (ncbitaxon:953) 
2023-06-07 | MSV000092124 | MassIVE
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