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ProteomicsAllogeneic antibodies specifically target AML antigen NuSAP1 after bone marrow transplantation
Identifying the targets of immune response after allogeneic hematopoietic cell transplantation (HCT) promises to provide relevant immune therapy candidate proteins. We used protein microarrays to serologically identify Nucleolar and Spindle Associated Protein 1 (NuSAP1) and Chromatin Assembly Factor...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-15255 | biostudies-arrayexpress
TranscriptomicsA human transcriptome array for high-throughput clinical studies (with a comparison to RNA-seq technology) [RNA-Seq]
A new high-density oligonucleotide array of the human transcriptome (GG-H array) has been developed for high-throughput and cost-effective analyses in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, as well as ...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-26109 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neutrophils isolated by microfluidics: Clinical Microfluidics for Neutrophil Genomics and Proteomics
Neutrophils play critical roles in modulating the immune response. However, neutrophils have a short circulating half life, are readily stimulated in vitro, and have low levels of cellular mRNA when compared to other blood leukocyte populations. All of these factors have made it difficult to evaluat...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22103 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukocytes after an inflammatory stimulus (bacterial endotoxin) to identify significant functional modules perturbed in response to this stimulus using network analysis
Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-3284 | biostudies-arrayexpress
TranscriptomicsGene response to major burn injuries
Blood was sampled from severe burns patients over time as well as healthy subjects. Genome-wide expression analyses were conducted using the Affymetrix U133 plus 2.0 GeneChip™. The Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program Blood was sampled from 244 seve...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-37069 | biostudies-arrayexpress
TranscriptomicsA genomic storm in critically injured humans
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “ge...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-36809 | biostudies-arrayexpress
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