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ProteomicsIdentification of transcription factors regulating CD22 transcription
CD22 (also known as Siglec-2) belongs to the Siglec family of glycan-recognition proteins and negatively regulates B-cell receptor-mediated signaling. CD22 protein is known to be down-regulated in the B cells of patients with chronic lymphocytic leukemia (CLL). However, the mechanism regulating the ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-26 | PXD054553 | Pride
Transcription factor B lymphocytes Burkitt lymphoma Minimal promoter Dna pull down-proteomics Cd22 Chronic lymphocytic leukemia 
TranscriptomicsRSC and ISW1 Chromatin Remodelers Display Functional and Chromatin-based Promoter Antagonism [ChIP-chip]
ISWI-family chromatin remodelers organize nucleosome arrays, while SWI/SNF-family remodelers (RSC) disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent genetic screens for rsc suppressors that yielded mutations in the promote...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-01 | E-GEOD-65589 | biostudies-arrayexpress
GenomicsHigh-Resolution Nucleosome Mapping Reveals Transcription-Dependent Promoter Packaging
Genome-wide mapping of nucleosomes has revealed a great deal about the relationships between chromatin structure and control of gene expression, and has led to mechanistic hypotheses regarding the rules by which chromatin structure is established. High-throughput sequencing has recently become the t...
ORGANISM(S): Saccharomyces cerevisiae 
2009-10-15 | E-GEOD-18530 | biostudies-arrayexpress
GenomicsSTARR-seq enhancer activity determined following hydrodynamic delivery of STARR-seq plasmid library to mouse liver using three different STARR-seq promoters: Super Core promoter, ORI promoter, and minimal Albumin promoter [G173]
STARR-seq enhancer activity determined following hydrodynamic delivery of STARR-seq plasmid library to mouse liver using three different STARR-seq promoters: Super Core promoter, ORI promoter, and minimal Albumin promoter [G173]
PRJNA1109709 | ENA
ProteomicsAnalysis of proteins that bind promoter of the PDR5 multidrug transporter gene in Saccharomyces cerevisiae using minichromosome isolation and LC-MS/MS
The Pleiotropic Drug Resistance (PDR) network is central to the drug response in fungi, and its overactivation is associated with drug resistance. However, gene regulation of the PDR network is not well understood. Here, we established a method to identify proteins that bind promoter of the PDR5 mul...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-22 | PXD028798 | Pride
Lc-msms Minichromosome Promoter-binding proteins Immunoprecipitation Saccharomyces cerevisiae 
GenomicsA minimal DNA sequence within the ARF promoter represses p16INK4A expression via long-range chromatin interaction [Capture-C]
A minimal DNA sequence within the ARF promoter represses p16INK4A expression via long-range chromatin interaction [Capture-C]
PRJNA517132 | ENA
UnknownA robust knock-in approach using a minimal promoter and a minicircle.
Not available
S-EPMC10516040 | biostudies-literature
TranscriptomicsPyrrole-imidazole polyamide targeted to the REL/ELK1 overlapping sequences in the EVI1 minimal promoter
Pyrrole-imidazole polyamides (PIPs) have been shown to inhibit gene expression by interrupting the DNA-protein interface. Human Ectopic viral integration site 1 (EVI1) is an oncogenic transcription factor which plays a key role in many aggressive forms of cancer. We have developed a novel pyrroleM-b...
ORGANISM(S): Homo sapiens 
2014-07-28 | E-GEOD-59502 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome
Background: Minimal change nephrotic syndrome (MCNS) is considered to be associated with T cell dysfunction, via unknown mechanisms. Experimental observations suggest that some humoral factors alter the permeability of glomerular filtration barrier. However, the nature of such factors remains still ...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-7349 | biostudies-arrayexpress
UnknownMinimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.
Not available
S-EPMC2757179 | biostudies-literature
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