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ProteomicsFive microRNAs in serum are able to differentiate breast cancer patients from healthy individuals
Breast Cancer is the cancer with most incidence and mortality in women. microRNAs are emerging as novel prognosis/diagnostic tools. Our aim was to identify a serum microRNA signature useful to predict cancer development. We focused on studying the expression levels of 30 microRNAs in the serum of 96...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD020795 | Pride
Micrornas Breast cancer Quantitative proteomics 
TranscriptomicsLentiviral vector-based microRNA sponges identifies miR-155 and miR-802 target genes in the hippocampus of Ts65Dn mice
A major challenge in Down syndrome (DS) is to understand how the extra-dose of functional chromosome 21 (HSA21) genetic elements can impact on the tissue-specific transcriptome to contribute to phenotypic alterations. MiRNAs are post-transcriptional modulators with genome-wide regulatory effects. F...
ORGANISM(S): Mus musculus 
2015-05-16 | E-GEOD-68074 | biostudies-arrayexpress
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
TranscriptomicsMicroRNA profiling of human acute myeloid leukemia samples from patients characterized for subcellular localization/mutation status of NPM1 and FLT3 mutations
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML and shows distinct features, including a unique gene expression profile. MicroRNAs (miRNAs) are small noncoding RNAs of 19-25 nucleotides in length that have been ...
ORGANISM(S): Homo sapiens 
2008-03-14 | E-TABM-429 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type or mir-155 deficient B cells after stimulation with LPS and IL4
Wild type or miR-155 deficient b cells from 5 individuals each were stimulated with LPS and IL4 for 24hs and profiled.
ORGANISM(S): Mus musculus 
2007-11-21 | E-MEXP-1325 | biostudies-arrayexpress
TranscriptomicsIdentification of tissue microRNAs predictive of sutinib activity in patients with metastatic renal cell carcinoma
Purpose: To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell carcinoma (MRCC) and to validate them in a cellular model. Selected microRNAs were studied in serum from MRCC patients and healthy individuals. Methods: We screened 673 microRNAs using TaqM...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-37766 | biostudies-arrayexpress
UnknownConcerted regulation of non-alcoholic fatty liver disease progression by microRNAs in apolipoprotein E-deficient mice.
Not available
S-EPMC8713993 | biostudies-literature
UnknownDynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Not available
S-EPMC3986124 | biostudies-literature
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsColony stimulating factor-1 receptor signaling networks inhibit macrophage inflammatory responses by induction of microRNA-21
Macrophage polarization between the M2 (repair, pro-tumorigenic) and M1 (inflammatory) phenotypes is seen as a continuum of states. The detailed transcriptional events and signals downstream of CSF-1R that contribute to amplification of the M2 phenotype and suppression of the M1 phenotype are largel...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-62630 | biostudies-arrayexpress
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