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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
ProteomicsSystematic analysis of intronic microRNAs reveals cooperativity within the multi-component FTX locus to promote colon cancer development
Approximately half of all microRNAs reside within intronic regions and are often co-transcribed with their host genes. However, most studies on intronic microRNAs focus on individual microRNAs, and conversely most studies on protein-coding and non-coding genes frequently ignore any intron-derived mi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD021823 | Pride
Micrornas A-to-i editing Colon cancer Long noncoding rna Post-transcriptional regulation 
TranscriptomicsNext-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection
HIV infection of CD4 T cells induces a range of host transcriptional changes in mRNAs as well as microRNAs that may coordinate changes in mRNAs. We applied next-generation sequencing, analyzing the small RNA fraction of HIV-infected cells at 5, 12, and 24 h postinfection (RNA-Seq).
ORGANISM(S): Homo sapiens 
2014-05-17 | E-GEOD-57763 | biostudies-arrayexpress
Proteomics,MultiomicsProteomics of U1810 cells upon treatment with microRNAs with an AAGUGC seed motif.
microRNA dysregulation is a common feature of cancer cells, but the complex roles of microRNAs in cancer are not fully elucidated. Here we used functional genomics to identify oncogenic microRNAs in non-small cell lung cancer and to evaluate their impact on response to EGFR targeting therapy. Our da...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080829 | MassIVE
ProteomicsFive microRNAs in serum are able to differentiate breast cancer patients from healthy individuals
Breast Cancer is the cancer with most incidence and mortality in women. microRNAs are emerging as novel prognosis/diagnostic tools. Our aim was to identify a serum microRNA signature useful to predict cancer development. We focused on studying the expression levels of 30 microRNAs in the serum of 96...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD020795 | Pride
Micrornas Breast cancer Quantitative proteomics 
TranscriptomicsDifferential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis
Endometriosis is defined as the presence of endometrial tissue (eutopic tissue) outside the uterus (ectopic tissue). We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium. Comparison of paired eutopic/ectopic endometrium microRNAs from three patients...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-26346 | biostudies-arrayexpress
ProteomicsProteomics of U1810 cells upon treatment with microRNAs with an AAGUGC seed motif.
microRNA dysregulation is a common feature of cancer cells, but the complex roles of microRNAs in cancer are not fully elucidated. Here we used functional genomics to identify oncogenic microRNAs in non-small cell lung cancer and to evaluate their impact on response to EGFR targeting therapy. Our da...
ORGANISM(S): Homo sapiens (Human) 
2016-06-28 | PXD004163 | Pride
Human Mirna Lc-ms Microrna U1810 Hirief 
ModelsProctor2017- Role of microRNAs in osteoarthritis (miR140 in osteoarthritis)
Proctor2017- Role of microRNAs in osteoarthritis (miR140 in osteoarthritis) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. Proctor CJ, Smith GR. PLoS ONE 2017; 12(11): e0187568 Abstract: ...
MODEL1705170005 | BioModels
ModelsProctor2017- Role of microRNAs in osteoarthritis (Negative Feedback By MicroRNA)
Proctor2017- Role of microRNAs in osteoarthritis (Negative Feedback By MicroRNA) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. Proctor CJ, Smi...
2024-09-02 | BIOMD0000000864 | BioModels
ModelsProctor2017- Role of microRNAs in osteoarthritis (Positive Feedforward Coherent By MicroRNA)
Proctor2017- Role of microRNAs in osteoarthritis (Positive Feedforward Coherent By MicroRNA) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. Proctor CJ, Smith GR. PLoS ONE 2017; 12(11): e018...
MODEL1610100003 | BioModels
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