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The aims of the study was to explore the tumor proteome of patients diagnosed with localized ccRCC and treated with surgery and the identification of altered pathways that could be the target of new treatments. A total of 165 FFPE tumor samples from patients diagnosed with ccRCC were analyzed using ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039258 | Pride
In order to identify direct or indirect miR-27a modulated genes, RH36 cells transfected with miR-27a precursors (pre-miR-27a or pre-control), analyzed 48h post-transfection, were used to perform microarray analysis. Gene expression profiling was carried out in ERMS cell line (RH36) transfected with...
ORGANISM(S): Homo sapiens 
We studied the value of the microRNAs as a signature for CLL patients with specific chromosomal abnormalities. We identified 32 microRNAs able to discriminate the 11q deletion, 17p deletion, trisomy 12, and 13q deletion and normal karyotype cytogenetic subgroups. The expression values of 9 among the...
ORGANISM(S): Homo sapiens 
The study sought to determine the global miRNA profiles of mouse pancreatic cell lines aTC1-6 and bTC1 at steady state and after treatment with a cocktail of pro-inflammatory cytokines (IL1b; IFNg and TNFa) for a time course of 24 and 48 hours. Inflammatory cocktail contains IL1b 50 IU/ml; IFNg 1000...
ORGANISM(S): Mus musculus 
The hypothesis that the onset and development of colorectal cancer result from the alteration of the close cooperation of mRNA-miRNA has gained increasing popularity. We performed a multifaceted enrichment analysis of hypernetworks, taking advantage of the simultaneous evaluation of transcriptome an...
ORGANISM(S): Homo sapiens 
Background. Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results. We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and 16 by high microsatellite instability, MSI-H)...
ORGANISM(S): Homo sapiens 
MicroRNAs (miRNAs), small non-coding RNAs that fine-tune gene expression, play multiple roles in the cell, including cell fate specification. We have analyzed the differential expression of miRNAs during fibroblast reprogramming into induced pluripotent stem cells (iPSCs) and endoderm induction in i...
ORGANISM(S): Mus musculus 
p53 suppresses tumor progression and metastasis by regulating a large set of genes and microRNAs. By profiling 92 primary hepatocellular carcinomas (HCCs) and 9 HCC cell lines, we found that p53 upregulates microRNAs including miR-200 and miR-192 family members. By sequencing TP53 in 92 HCC samples,...
ORGANISM(S): Homo sapiens 
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