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TranscriptomicsMicroRNAs and their target genes in gingival tissues.
To gain insights into the in vivo function of miRNAs in the context of periodontitis, we examined the occurrence of miRNAs in healthy and diseased gingival tissues and validated their in silico-predicted targets through mRNA profiling using whole-genome microarrays in the same specimens. Eighty-six ...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54710 | biostudies-arrayexpress
TranscriptomicsIncreases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood.
Lifestyle intervention can improve insulin sensitivity in obese youth yet few studies have examined the biological mechanisms underlying improvements. Therefore, the purpose of this study was to explore biological pathways associated with intervention-induced improvements in insulin sensitivity. Fif...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-50800 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of human astrocytomas
Pediatric astrocytomas, a leading cause of death associated with cancer, are the most common primary central nervous system tumors found in children. Most studies of these tumors focus on adults, not children. We examined the global protein and microRNAs expression pattern by 2D SDS-PAGE, mass spect...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44280 | biostudies-arrayexpress
UnknownIn the presence of non-neutralising maternally derived antibodies, intradermal and intramuscular vaccination with a modified live vaccine against porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) induce similar levels of neutralising antibodies or interferon-gamma secreting cells.
Not available
S-EPMC9636649 | biostudies-literature
TranscriptomicsCharacterization of human plasma-derived exosomal RNAs
Exosomes, endosome-derived membrane microvesicles, contain a specific set of RNA transcripts that are involved in cell-cell communication and hold a great potential as disease biomarkers. To systemically characterize exosomal RNA profiles, we performed RNA sequencing analysis using three human plasm...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-GEOD-45722 | biostudies-arrayexpress
TranscriptomicsExpression of miR-196a in Huntington's disease transgenic (HD) mice
We intend to screen altered genes after overexpression of miR-196a in HD transgenic mice. Two transgenic mouse lines were used in this study, including HD transgenic mice and HD transgenic mice overexpressing miR-196a. The mice were all at approximate 12 months of age. At this point, HD transgenic ...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-47500 | biostudies-arrayexpress
TranscriptomicsmiR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-54494 | biostudies-arrayexpress
TranscriptomicsLarge-scale identification and comparative analysis of miRNA expression profile in the respiratory tree of the sea cucumber Apostichopus japonicus during aestivation (part 1)
The sea cucumber Apostichopus japonicus withstands high water temperatures in the summer by suppressing metabolic rate and entering a state of aestivation. We hypothesized that changes in the expression of miRNAs could provide important post-transcriptional regulation of gene expression during hypom...
ORGANISM(S): Apostichopus japonicus 
2014-10-01 | E-GEOD-52224 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression during ovine adult mammary gland development
The mammary gland undergoes extensive remodeling between the begin- ning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation, and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we descr...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-32654 | biostudies-arrayexpress
TranscriptomicsDevelopment of microRNA expression signatures in laryngeal tumors
Background: MicroRNA (miRNA) is an emerging subclass of small non-coding RNAs that regulates gene expression and has a pivotal role for many physiological processes including cancer development. Recent reports revealed the role of miRNAs as ideal biomarkers and therapeutic targets due to their tissu...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-47610 | biostudies-arrayexpress
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