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TranscriptomicsAbsolute quantification of miRNAs
MicroRNAs (miRNAs) have been shown to play an important role in many different cellular, developmental, and physiological processes. Accordingly, numerous methods have been established to identify and quantify miRNAs. The shortness of miRNA sequence results in a high dynamic range of melting tempera...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-15835 | biostudies-arrayexpress
TranscriptomicsInvolvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a co...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-51648 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs and their target genes in developing seeds of soybean by deep sequencing
In our study, small RNA library and degradome library were constructed from developing soybean seeds for deep sequencing. We identified 26 new miRNAs in soybean by bioinformatic analysis, and further confirmed their expression by stem-loop RT-PCR. The miRNA star sequences of 38 known miRNAs and 8 ne...
ORGANISM(S): Glycine max 
2010-11-11 | E-GEOD-25260 | biostudies-arrayexpress
TranscriptomicsRelative quantification of miRNAs across multiple experiments
MicroRNAs (miRNAs) have been shown to play an important role in many different cellular, developmental, and physiological processes. Accordingly, numerous methods have been established to identify and quantify miRNAs. The shortness of miRNA sequence results in a high dynamic range of melting tempera...
ORGANISM(S): synthetic construct 
2010-06-20 | E-GEOD-15833 | biostudies-arrayexpress
ProteomicsPlasma extracellular vesicle miRNA profiling in cervical cancer patients and healthy controls
Cervical cancer (CC) is a malignancy characterized by persistent HPV infection and tumor microenvironment remodeling. To explore the molecular characteristics of plasma extracellular vesicles (EVs) in CC, we performed miRNA sequencing on plasma EVs from 3 CC patients and 3 healthy controls. Differen...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071100 | Pride
Cervical cancer Blood 
TranscriptomicsIdentification of miRNAs and their target genes in developing maize ears by deep sequencing
In plants, MicroRNAs (miRNAs) are a new class of endogenous small RNAs that play essential regulatory roles in plant growth, development and stress response. Extensive studies of miRNAs have been performed in model plants such as rice, Arabidopsis thaliana and other plants. However, the number of mi...
ORGANISM(S): Zea mays 
2014-10-22 | E-GEOD-47837 | biostudies-arrayexpress
TranscriptomicsSmall RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich's ataxia patients
Friedreich’s ataxia (FRDA; OMIM 229300), an autosomal recessive neurodegenerative mitochondrial disease, is the most prevalent hereditary ataxia. In addition, FRDA patients showed additional non-neurological features such as scoliosis, diabetes and cardiac complications. Hypertrophic cardiomyopathy,...
ORGANISM(S): Homo sapiens 
2017-10-18 | E-GEOD-105052 | biostudies-arrayexpress
Transcriptomicsp53- repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation
There is a distinctive miRNA expression profile between early (young) and replicative senescence (old). We observed a cluster of miRNAs that were repressed upon senescence in both MRC-5 and WI-38 fibroblast cells. miRNAs profiling in young and senescence human emryonic fibroblasts (MRC-5 and WI-38)
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-12821 | biostudies-arrayexpress
TranscriptomicsA Comprehensive Genome-wide Study on Tissue- and Abiotic Stress-specific miRNAs in Triticum aestivum
Purpose: To identify abiotic stress responsive and tissue specific miRNAs at genome wide level in wheat (Triticum aestivum) Results: Small RNA libraries were constructed from four tissues (root, shoot, mature leaf and spikelets) and three stress treatments of wheat seedlings (control, high temperat...
ORGANISM(S): Triticum aestivum 
2014-08-20 | E-GEOD-53487 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs in Amur grapevine
MicroRNA (miRNA) is a class of functional non-coding small RNA with 19-25 nucleotides in length. Amur grape (Vitis amurensis Rupr.) is an important wild fruit crop with the strongest cold resistance in the Vitis genus and is used as an excellent breeding parent for grapevine, and with growing inter...
ORGANISM(S): Vitis amurensis 
2011-12-16 | E-GEOD-34169 | biostudies-arrayexpress
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