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While fewer cases of severe Coronavirus Disease 2019 (COVID-19) are reported globally in children, a small proportion of SARS-CoV-2 infected children develop a novel pediatric febrile entity called multisystem inflammatory syndrome in children (MIS-C) that develops 2 to 5 weeks after initial SARS-Co...
ORGANISM(S): Homo sapiens (Human) 
2021-09-29 | PXD025462 | Pride
The pathologic mechanisms causing Multisystem 38 Inflammatory Syndrome in Children (MIS-C) are not yet known; we sought to use high throughput proteomics to uncover signatures of dysregulation suggestive of pathophysiology fo this condition. MIS-C is a major complication of the Severe Acute Respirat...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD029375 | Pride
To identify a diagnostic blood transcriptomic signature that distinguishes multisystem inflammatory syndrome in children (MIS-C) from Kawasaki Disease (KD), bacterial infections and viral infections. Children presenting with MIS-C to participating hospitals in the United Kingdom and the European Uni...
Single cell transcriptomic data from CD4+ T cells from children with MIS-C
Single cell transcriptomic data from CD4+ T cells from children with MIS-C
Rapid Acceleration of Diagnostics - Radical (RADx-rad): Diagnosis of MIS-C in Febrile Children
Rapid Acceleration of Diagnostics - Radical (RADx-rad): Diagnosis of MIS-C in Febrile Children
Background: COVID-19 has infected more than 100-million worldwide. Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Methods: We utilised SWATH-MS proteomics to determi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD025125 | Pride
Epigenetic Profiling Linked to Multisystem Inflammatory Syndrome in Children (MIS-C): A Multicenter, Retrospective Study
An Improved Understanding of the Aetiology and Diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C)
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