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ProteomicsMiRNA 3’ ends shorten during adolescent brain maturation
MicroRNA (miRNA) dysregulation is well-documented in psychiatric disease, but miRNA dynamics during adolescent and early adult brain maturation, when symptoms first appear for many of these diseases, remain poorly understood. Here, we use RNA sequencing to examine miRNAs and their mRNA targets in co...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-17 | PXD040229 | Pride
Mirna Cortex Proteomics Rna-seq 
ProteomicsProfiling changes to the global proteome in HEK293T cells in response to heat stress. (PMID: 34739326)
Here we have determined changes to the global proteome in response to heat stress. The abundance of individual proteins was compared between heat stressed and untreated control HEK293T cells in the presence of proteasome inhibition using quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD069754 | Pride
Proteasome Stress response Ubiquitin Proteome 
ProteomicsProfiling changes to the global proteome in HEK293T cells in response to heat stress. Total Proteome TMT data PMID 34739326.
Here we have determined changes to the global proteome in response to heat stress. The abundance of individual proteins was compared between heat stressed and untreated control HEK293T cells in the presence of proteasome inhibition using quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD070122 | Pride
ProteomicsAltered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation
GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions where it interacts with synaptic proteins/receptors and regulates Ca2+ signaling.
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD042994 | Pride
Membrane contact sites (mcs) Glycosphingolipids (gsls) Proteomics 
ProteomicsDRAK2 alters IL-2 sensitivity and Treg development
Drak2¬-deficient (Drak2-/-) mice are resistant to multiple models of autoimmunity, yet effectively eliminate pathogens and tumors. Thus, DRAK2 is an ideal target to treat autoimmune diseases. However, the mechanisms by which DRAK2 contributes to autoimmunity, particularly type 1 diabetes (T1D), rema...
ORGANISM(S): Homo sapiens (Human) 
2023-02-09 | PXD037922 | Pride
Regulatory t cells Type 1 diabetes T cells Tolerance Thymus Il-2 
UnknownMAPK cascade gene family in Camellia sinensis: In-silico identification, expression profiles and regulatory network analysis.
Not available
S-EPMC7487466 | biostudies-literature
TranscriptomicsExpression data in response to abiotic stresses in tomato at flowering stage
A comparative study ware made to know the abiotic stress tolerance machanism between tolerant and susceptible plants at flowering stage. The tolerance in response to abiotic stresses are sum of expression of thousands of genes at a particular stage. Tomato plants were exposed to drought and heat str...
ORGANISM(S): Solanum lycopersicum 
2010-06-23 | E-GEOD-22304 | biostudies-arrayexpress
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