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ProteomicsGlutamine missense suppression transfer RNAs inhibit polyglutamine aggregation
Mass spectrometry confirmed Ala mis-incorporation in polyQ, demonstrating misincorporation at each position in polyQ at a level of ~10% Ala at Gln codons. Cells expressing the missense suppressor tRNAs showed no growth defect or significant changes in cytotoxicity. Our findings demonstrate that tRNA...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-15 | PXD053115 | Pride
Transfer rna Mistranslation Huntington's disease Polyq 
UnknownCancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.
Not available
S-EPMC11002309 | biostudies-literature
UnknownAcetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers.
Not available
S-EPMC10391690 | biostudies-literature
UnknownProteostasis Modulation in Germline Missense von Hippel Lindau Disease.
Not available
S-EPMC10330138 | biostudies-literature
UnknownGlutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation.
Not available
S-EPMC11787650 | biostudies-literature
TranscriptomicsSuppression of prp28-1 splicing defect by prp8-tes allele
DEAD-box proteins, a family of RNA-dependent ATPases, promote the numerous conformational rearrangements required for spliceosome assembly, activation, and disassembly. Previous work showed that a cold-sensitive substitution in DEAD-box protein Prp28 prevents the switch from U1 to U6 snRNA pairing w...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-01 | E-GEOD-42754 | biostudies-arrayexpress
UnknownThe Promiscuous sumA Missense Suppressor from Salmonella enterica Has an Intriguing Mechanism of Action.
Not available
S-EPMC5289838 | biostudies-literature
UnknownCeramide-Rubusoside Nanomicelles, a Potential Therapeutic Approach to Target Cancers Carrying p53 Missense Mutations.
Not available
S-EPMC7007850 | biostudies-literature
GenomicsPLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis
PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis
PRJNA835205 | ENA
UnknownSuppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production.
Not available
S-EPMC6029885 | biostudies-literature
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