Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
Mitochondria transplantation is a hot spot in cell-free therapy. Menstrual stem cells (MenSCs) are potential donor cells to provide foreign mitochondria. This study aims to investigate the possible effects of MenSC-derived mitochondria on ovarian cancer from the perspective of protein expression pro...
This study performed bulk RNA sequencing to characterize the transcriptomic changes induced by mitochondria transplantation in human keloid fibroblasts (KFs). Primary human keloid fibroblasts were treated with adipose-derived stem cell-derived mitochondria, and global gene expression profiles were c...
Mitochondria exhibit diverse effects on cellular responses. Mitochondrial transplantation from gastric epithelial cells GES-1 to gastric cancer cells AGS reduces cancer malignancy was previously reported. We employed proteomic and metabolomic analyses to elucidate underlying mechanisms. iTRAQ/TMT-ba...
