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ProteomicsIdentification of proteins associated with the human mitochondrial degradosome
The human mitochondrial degradosome is a complex of the ribonuclease PNPase (Q8TCS8, encoded by PNPT1 gene) and RNA helicase SUV3 (Q8IYB8, encoded by SUPV3L1 gene). The aim of the project was to identify proteins which co-purify with both subunits of the degradosome. To this end we used human 293 ce...
ORGANISM(S): Homo sapiens (Human) 
2018-07-06 | PXD009826 | Pride
Mitochondrial rna Supv3l1 Suv3 Pnpt1 Mitochondrial degradosome Pnpase 
GenomicsCooperation of GRSF1 and the mitochondrial degradosome (hSuv3-PNPase complex) in degradation of mitochondrial RNA
Cooperation of GRSF1 and the mitochondrial degradosome (hSuv3-PNPase complex) in degradation of mitochondrial RNA
PRJNA416454 | ENA
UnknownHuman mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
Not available
S-EPMC6205488 | biostudies-literature
TranscriptomicsCooperation of GRSF1 and the mitochondrial degradosome (hSuv3-PNPase complex) in degradation of mitochondrial RNA
Vertebrate mitochondrial genomes show extraordinary GC skew which results in the synthesis of RNAs prone to form G-quadruplexes (G4). Such RNAs, although mostly non-coding, are transcribed at high rate and swiftly degraded by an unknown mechanism. Comprehensive proteomic and transcriptomic approache...
ORGANISM(S): Homo sapiens 
2018-06-17 | GSE106368 | GEO
UnknownEvidence for a degradosome-like complex in the mitochondria of Trypanosoma brucei.
Not available
S-EPMC2723791 | biostudies-literature
UnknownSplicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP).
Not available
S-EPMC2838280 | biostudies-literature
UnknownDimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay.
Not available
S-EPMC9044407 | biostudies-literature
UnknownYeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex.
Not available
S-EPMC3287206 | biostudies-literature
UnknownMitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.
Not available
S-EPMC6468249 | biostudies-literature
UnknownBeyond a platform protein for the degradosome assembly: The Apoptosis-Inducing Factor as an efficient nuclease involved in chromatinolysis.
Not available
S-EPMC9944232 | biostudies-literature
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