The human mitochondrial degradosome is a complex of the ribonuclease PNPase (Q8TCS8, encoded by PNPT1 gene) and RNA helicase SUV3 (Q8IYB8, encoded by SUPV3L1 gene). The aim of the project was to identify proteins which co-purify with both subunits of the degradosome. To this end we used human 293 ce...
Eukaryotic cells have two separate genomes that are replicated independently; nuclear DNA organized in chromosomes and circular DNA within mitochondria. Mitochondrial DNA is transcribed bi-directionally to generate mitochondrial RNA (mtRNA). As a by-product of the bi-directional transcription, dsRNA...
