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TranscriptomicsIdentification of markers associated with deregulated hTERT during HPV-medaited transformation
Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit hTERT. Our previo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8288 | biostudies-arrayexpress
ProteomicsMitochondrial hTERT rewires glucose metabolism to confer cancer chemoresistance by binding to MT-ND1
To find the influence of mitochondrial hTERT on glucose metabolism and chemoresistance and to further investigate the underlying mechanism.
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD036126 | Pride
Chemoresistance Mt-nd1 Mitochondrial htert Glucose metabolism 
GenomicsWhole genome sequencing of RPE1-hTERT-DAAO^H2B P53KO and RPE1-hTERT-DAAO^TOM20 P53KO cells
Whole genome sequencing of RPE1-hTERT-DAAO^H2B P53 KO and RPE1-hTERT-DAAO^TOM20 P53KO cells
PRJEB72014 | ENA
TranscriptomicshTERT promotes cell adhesion and migration independent of telomerase activity
We sequenced mRNA from 6 human cell lines stably over-expressed specific gene or empty vector, and searched for differently expressed genes after gene over-expression as compared to empty vector. mRNA levels were compared as following pairs: U2OS+hTERT vs U2OS+vector; U2OS+hTERTmut vs U2OS+vector; V...
ORGANISM(S): Homo sapiens 
2015-09-22 | E-GEOD-73277 | biostudies-arrayexpress
UnknownSmall-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.
Not available
S-EPMC6713458 | biostudies-literature
ProteomicsMass spectrum for identifying the interacting proteins of telomerase reverse transcriptase
The 293T cells overexpressing human telomerase reverse transcriptase (hTERT) were lysed and co-immunoprecipitation was performed using hTERT antibody. Then protein mass spectrum was conducted in order to identify the hTERT-interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD048859 | Pride
Chemoresistance Mt-nd1 Mitochondrial htert Glucose metabolism 
UnknownDiscovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through upregulating hTERT induces cell apoptosis and ERS.
Not available
S-EPMC5596570 | biostudies-literature
UnknownGV1001, an hTERT-Derived Peptide, Prevents Cisplatin-Induced Nephrotoxicity by Preserving Mitochondrial Function.
Not available
S-EPMC12651939 | biostudies-literature
UnknownHuman telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1.
Not available
S-EPMC7280311 | biostudies-literature
GenomicsMitochondrial Iron Sensitizes Senescent Cancer Cells to Ferroptosis
Mitochondrial Iron Sensitizes Senescent Cancer Cells to Ferroptosis
PRJNA1434172 | ENA
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