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ProteomicsProteolytic Cleavage Activates the Mitochondrial Isoform of TOP3A
The TOP3A gene encodes two isoforms, one targeted to the nucleus and one to mitochondria. Nuclear TOP3A functions as part of the BTRR complex to resolve double Holliday junctions during homologous recombination, while the mitochondrial isoform separates hemicatenated daughter mitochondrial DNA molec...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD064926 | Pride
Top3a Mitochondria Mitochondrial processing peptidase (mmp) Proteolytic cleavage product 
TranscriptomicsSema4A, a novel serum marker of multiple sclerosis, implicates Th17 pathology and efficacy of interferon-β.
Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system and the leading cause of lasting neurological disabilities in young adults. Increasing evidence suggests that early treatment prevents the development of disability. However, there have been no re...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26484 | biostudies-arrayexpress
TranscriptomicsMultinucleated Tartrate Resistant Acid Phosphatase Positive Cells with Macrophage and Osteoclast Phenotypes in Bone
Prothrombin (PT) and osteopontin (OPN) promotes adhesion of different TRAP-positive multinucleated cells isolated from rat long bone (Hu et al. Exp Cell Res. 2008; 314: 638-50). The PT-adhering cell could represent either an immature precursor to the OPN-adherent osteoclast or constitute a distinct...
ORGANISM(S): Rattus norvegicus 
2010-12-31 | E-GEOD-19950 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ANA-1 macrophages infected with Chlamydia pneumoniae
This experiment is an additional experiment to GSE6688. Mouse macrophages (ANA-1 cells) were infected in vitro with C. pneumoniae with a M.O.I. of 10. Twenty two genes were significantly upregulated. Examples of the most upregulated genes in mouse macrophages after C. pneumoniae infection are serum ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6690 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of M. tuberculosis constitutively expressing the transcriptional regulator DosR (Rv3133c).
Background: Conflicting results have been reported about the role of the two-component sensor and transcriptional regulator DosS/DosR, controlling the expression of the dormancy DosR regulon, for in vivo virulence of M. tuberculosis. Here, we have used a new approach to further analyze the relevance...
ORGANISM(S): Mycobacterium tuberculosis 
2012-06-12 | E-GEOD-19838 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNAs in Heliconius melpomene
Background: Heliconius butterflies are an excellent model system for studies of adaptive convergent and divergent phenotypic traits. Wing colour patterns are used as signals to both predators and potential mates and are inherited in a Mendelian manner. The underlying genetic mechanisms of pattern fo...
ORGANISM(S): Heliconius melpomene melpomene 
2011-06-02 | E-GEOD-23292 | biostudies-arrayexpress
TranscriptomicsFF and FFPE HPV+ and HPV- HNSCC and HNSCC cell lines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38271 | biostudies-arrayexpress
Transcriptomics450k Analysis of 42 FFPE HPV+ and HPV- HNSCC samples
The methylation analysis of 21 FFPE HPV+ HNSCC samples and 21 FPPE HPV- HNSCC samples by Infinium HumanMethylation450 BeadChip Analysis of 42 450k methylation profiles, comprising 21 HPV+ HNSCC samples and 21 HPV- HNSCC samples
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38266 | biostudies-arrayexpress
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