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MetabolomicsSARS-CoV-2 ORF7a Drives Mitochondrial Dysfunction via PDK4 Activation and Complex I Inhibition

SARS-CoV-2 reprograms host metabolism to promote viral replication and evade immune responses. While infection is known to impair mitochondrial function and enhance glycolysis, the role of viral accessory proteins in these alterations remains unclear. Here, we investigate the metabolic impact of ...

2026-07-09 | MTBLS13338 | MetaboLights
MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
TranscriptomicsTranscription profiling of yeast rho0 cells (complete deletion of the mitochondrial genome), in cells with either a single defective enzyme or several, vs cells after prolonged treatment with the bc1 inhibitors myxothiazol or antimycin to analyse respiratory defects
The mitochondrial respiratory chain is composed of lipoprotein complexes imbedded in the inner mitochondrial membrane. This chain of enzymes transfers electrons from NADH and FADH2, provided from divers metabolic pathways, to oxygen. It couples the transfer of electrons to the translocation of proto...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-20 | E-MEXP-585 | biostudies-arrayexpress
ProteomicsRTN4IP1 is essential for the final stages of mitochondrial complex I assembly
A biochemical deficiency of mitochondrial complex I (CI) underlies ~30% of cases of primary mitochondrial disease, yet the inventory of molecular machinery required for CI assembly remains incomplete. We previously characterised patients with isolated CI deficiency caused by segregating variants in ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD055511 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i assembly 
ProteomicsSalvage pathway maintains functional respiratory complex I
Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain complex remains enigmatic, despite huge advancement in understanding its structure and the assembly steps in recent years. Although some studies indicated that CI might be remodelled in response to various stim...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD014897 | Pride
Mitochondrial respiratory complex i  proteolytic control  salvage pathway  respiratory deficiency  clpxp protease 
TranscriptomicsTranscription profiling of human fibroblast RNA from patient with a mitochondrial oxidative phosphorylation complex I deficency vs normal fibroblast RNA
Comparison of fibroblast RNA from patient with a mitochondrial oxidative phosphorylation complex I deficency to normal fibroblast RNA.

Note: this experiment submission is not fully MIAME compliant, due to the unavailability of oligonucleotide sequences on the A-MEXP-70 array ("Adelaide, H.sap...
ORGANISM(S): Homo sapiens 
2004-09-01 | E-MEXP-118 | biostudies-arrayexpress
ProteomicsHIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV
Assembly factors play a critical role in the biogenesis of mitochondrial respiratory chain complexes I-IV where they assist in the membrane insertion of subunits, attachment of co-factors, and stabilization of assembly intermediates. The major fraction of complexes I, III and IV are present together...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD016864 | Pride
Assembly factor Cytochrome c oxidase Hypoxia Respirasome Oxphos 
ProteomicsThe assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathog...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-12-13 | PXD042905 | Pride
Keywords: oxidative phosphorylation (oxphos) Mitochondrial complex i assembly complex (mcia) Fatty acid oxidation (fao) Amyloid-β Ecsit phosphorylation Cryo-em 
ProteomicsSodium carbonate extraction mass spectrometry reveals novel steps in mitochondrial respiratory chain complex III assembly
Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or as integral membrane proteins, while others reside...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD028935 | Pride
Proteomic analysis Mitochondria Oxphos (oxidative phosphorylation) Carbonate extraction Respiratory chain assembly Membrane protein 
ProteomicsThe structural mechanism of MCIA complex assembly links mitochondrial redox pathways
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathog...
ORGANISM(S): Escherichia coli 
2023-12-13 | PXD042858 | Pride
Oxidative phosphorylation (oxphos) Mitochondrial complex i assembly complex (mcia) Fatty acid oxidation (fao) Amyloid-β Ecsit phosphorylation Cryo-em 
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