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ProteomicsUnraveling the complexities of mitochondrial supercomplexes by mass spectrometry-based proteomics
It is now accepted that mitochondrial respiratory complex subunits assemble in supercomplexes. However, studying supercomplexes has typically relied upon antibody-based protein quantification, often limited to a single subunit per respiratory complex. To provide a deeper insight into mitochondrial p...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-17 | PXD016289 | Pride
Oxidative phosphorylation Mitochondrial supercomplexes Blue native gel Mitochondrial respiratory complexes Protein complex proteomics 
GenomicsReorganization of Mitochondrial Respiratory Supercomplexes Induces Myoblasts Differentiation
Reorganization of Mitochondrial Respiratory Supercomplexes Induces Myoblasts Differentiation
PRJNA739645 | ENA
ProteomicsComplexome profiling of human cybrids laking mitochondrial genes Cox1 or Cox2
Mitochondrial respiratory chain (MRC) complexes I, III and IV are associated into large molecular structures named supercomplexes (SCs) or respirasomes, whose functional roles remain to be fully understood. Biochemical analyses in a diversity of OXPHOS-deficient cellular and animal models support th...
ORGANISM(S): Homo sapiens (Human) 
2020-07-01 | PXD017840 | Pride
Cybrids Mitochondria Supercomplexes Complexome profiling 
UnknownAssembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.
Not available
S-EPMC6056720 | biostudies-literature
UnknownThe functional significance of mitochondrial respiratory chain supercomplexes.
Not available
S-EPMC10626428 | biostudies-literature
UnknownOpen questions: respiratory chain supercomplexes-why are they there and what do they do?
Not available
S-EPMC6211484 | biostudies-literature
UnknownMitochondrial ferredoxin-like is essential for forming complex I-containing supercomplexes in Arabidopsis.
Not available
S-EPMC10069907 | biostudies-literature
UnknownRespiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV.
Not available
S-EPMC6996572 | biostudies-literature
ProteomicsProteomic analysis of ∆4-CYB complex III mutant cybrids
The mitochondrial respiratory chain (MRC) enzymes associate in supercomplexes (SC). This structural interdependency may explain why defects in a single component often produce combined enzyme deficiencies in patients. A point in case is the alleged destabilization of complex I in the absence of com...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016521 | Pride
Human Mitochondria 
UnknownStructural rather than catalytic role for mitochondrial respiratory chain supercomplexes.
Not available
S-EPMC10569793 | biostudies-literature
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