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TranscriptomicsGenotyping of 75 individuals from the Afrikaner population of South Africa
The Afrikaner population of South Africa are the descendants of European colonists who started to colonize the Cape of Good Hope in the 1600s. In the early days of the colony, mixed unions between European males and non-European females gave rise to admixed children who later became incorporated int...
ORGANISM(S): Homo sapiens 
2020-01-28 | E-MTAB-8757 | biostudies-arrayexpress
GenomicsPyropia dentata
Neoporphyra dentata haenam mitochondrial DNA, complete genome
PRJDB12447 | ENA
GenomicsMethanobacterium formicicum DSM 3637
Methanobacterium formicicum DSM3637 Genome Sequencing
PRJNA169610 | ENA
TranscriptomicsLamin A/C expression in hematopoietic cells declines during human aging and constrains atherosclerosis in mice
Aging is the main risk factor for atherosclerotic cardiovascular disease, a condition caused by immune cells that leads to the buildup of plaques in arteries and is the top cause of death worldwide. Earlier studies on premature aging diseases have linked this condition to problems with A-type lamins...
ORGANISM(S): Mus musculus 
2025-11-06 | E-MTAB-15242 | biostudies-arrayexpress
TranscriptomicsEndothelial YAP/TAZ activation is a key mediator of atherosclerosis in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the expression of progerin, an aberrant protein produced by a de novo point mutation in the LMNA gene. HGPS patients show accelerated aging and die prematurely, mainly from atherosclerosis complications. Understanding...
ORGANISM(S): Mus musculus 
2024-10-17 | E-MTAB-13678 | biostudies-arrayexpress
ProteomicsOxygen sensitive regulation of TFAM linking the von Hippel-Lindau cancer syndrome to impaired mitochondrial biogenesis
The major consumers of oxygen in the cell are mitochondria. Here we identified an oxygen-sensitive regulation of TFAM, a key activator of mitochondrial transcription and replication. TFAM is hydroxylated by EglN3 on proline 53/56 and subsequently bound by the tumor suppressor von Hippel Lindau (pVHL...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD022734 | Pride
Lc-ms/ms Tmt Mitocondria Hippel-lindau cancer syndrome Oxygen regulation 
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