Lamin A/C expression in hematopoietic cells declines during human aging and constrains atherosclerosis in mice

ABSTRACT: Aging is the main risk factor for atherosclerotic cardiovascular disease, a condition caused by immune cells that leads to the buildup of plaques in arteries and is the top cause of death worldwide. Earlier studies on premature aging diseases have linked this condition to problems with A-type lamins, important parts of the cell’s nuclear envelope. In this study, we looked at how aging changes the levels of lamin A/C in white blood cells and how changing these levels in blood-forming cells affects their behavior and the development of atherosclerosis Atheroprone Ldlr-/- mice were used as recipients in BM transplantation (BMT) experiments. During 4 weeks after BMT, mice were on standard diet for BM reconstitution and then placed on a high-fat diet (HFD) for 6 weeks to induce hypercholestero

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Carlos Torroja 

PROVIDER: E-MTAB-15242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress