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ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
ProteomicsSelf-priming of Plk1 binding to BubR1 ensures accurate mitotic progression
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096264 | MassIVE
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based ...
2024-09-02 | BIOMD0000000187 | BioModels
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering ...
2024-09-02 | BIOMD0000000186 | BioModels
ProteomicsJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (IGX-MS data)
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome (APC/C). The Mad1-Mad2 complex provides a catalytic platform for MCC assembly. Mad1-...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031872 | Pride
Cell cycle  spindle assembly checkpoint  mad1  bub1  cdc20  mitotic checkpoint complex 
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
This dataset consists of 1 raw MS file and associated peak list and result file, acquired on an Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication. Publication title: "JAK2-CHK2 signaling safeguards the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-31 | MSV000087138 | MassIVE
ProteomicsMps1 Phosphorylation of the Molecular Chaperone Hsp90 Regulates Mitotic Checkpoint
SUMMARY Mps1 protein kinase is required for accurate chromosome segregation during the mitotic checkpoint. The molecular chaperone Heat Shock Protein 90 (Hsp90) has been linked to Mps1 activity, however the molecular mechanismsunderlying this regulatory process remain elusive. We report that Mps1 d...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-01-27 | PXD001969 | Pride
Mitotic checkpoint Molecular chaperones Heat shock protein 90 Mps1 Phosphatase Kinase Phosphorylation Cdc14 
ProteomicsHs_MitoticExit_Phos_Silac_IT
Global phosphoproteomic mapping of early mitotic exit in human hela cells, ITCID
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005294 | PeptideAtlas
ProteomicsHs_MitoticExit_Phos_Silac_HCD
Global phosphoproteomic mapping of early mitotic exit in human hela cells, HCD
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005254 | PeptideAtlas
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD056821 | Pride
Phosphorylation Chk2 Lc-ms/ms 
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