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ProteomicsReverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells
To determine the biological effects of MPS1 inhibition (both by siRNA and Drug (NMSP715)) on signaling pathways in GBM cells (U251 &U87), we profiled the modulation of phosphorylated and non-phosphorylated proteins using RPPA Relative protein levels for each sample were determined by interpolation o...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-67502 | biostudies-arrayexpress
TranscriptomicsGene based expression changes in glioblastoma cells after downregulation of MPS1 kinase
Gene expression changes were analyzed in U251 GBM cells after downregulation of MPS1 by RNA interference technology at different time points Microarray analysis was used to compare the mRNA expression profile of siMPS1 silenced U251 cells compared to siNegative (siNeg) and untransfected (Control) ce...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-57091 | biostudies-arrayexpress
ProteomicsProximity-based activation of AURORA A by MPS1 potentiates error correction
Faithfull cell division relies on mitotic chromosomes becoming bioriented with each pair of sister kinetochores bound to microtubules from opposing spindle poles. Erroneous kinetochore- microtubule attachments often form during early mitosis, but are destabilized through the phosphorylation of outer...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-03 | PXD056173 | Pride
Auroraa In vitro phosphorylation assay Mitosis 
ProteomicsMps1 Phosphorylation of the Molecular Chaperone Hsp90 Regulates Mitotic Checkpoint
SUMMARY Mps1 protein kinase is required for accurate chromosome segregation during the mitotic checkpoint. The molecular chaperone Heat Shock Protein 90 (Hsp90) has been linked to Mps1 activity, however the molecular mechanismsunderlying this regulatory process remain elusive. We report that Mps1 d...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-01-27 | PXD001969 | Pride
Mitotic checkpoint Molecular chaperones Heat shock protein 90 Mps1 Phosphatase Kinase Phosphorylation Cdc14 
ProteomicsMps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation
Spindle assembly checkpoint (SAC) regulators such as the Mps1 kinase not only delay anaphase onset, but also correct improper chromosome-spindle linkages that would otherwise lead to missegregation and aneuploidy. However, the substrates and mechanisms involved in this pathway of error correction re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006135 | Pride
Proteomics Mps1 Chemical genetics Ska complex Spindle assembly checkpoint (sac) Pp2a-b56 
GenomicsA common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint
A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint
PRJNA604761 | ENA
ProteomicsIn vitro phosphorylation of Dam1 complex and Bim1 by Mps1
The Dam1 complex (Dam1c) of Saccharomyces cerevisiae is a major microtubule binding component of the yeast kinetochore. Phosphorylation of various kinetochore proteins by mitotic kinases such as Mps1 are known to modulate the function of these proteins and regulate protein-protein interaction. The D...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD047005 | Pride
Mps1  phosphorylation Dam1 Mass spectrometry 
ProteomicsGreatwall kinase regulates SAC by controlling phosphorylation and activity of MPS1
The Greatwall/Mastl kinase is an essential gene, which regulates the phosphatase activity that counteracts the phosphorylation of Cdk1 substrates. Although Mastl-/- MEFs can enter mitosis, they are unable to complete mitosis due to chromosome segregation defects. Here, we show that Mastl is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004882 | Pride
Greatwall kinase/mastl/cyclin-dependent kinase/knockout mice/cdk1/mps1/sac 
GenomicsA common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint
The conserved Mps1 kinase corrects improper kinetochore-microtubule attachments, thereby ensuring chromosome biorientation. Yet, its critical targets in this process remain elusive. Mps1 is also involved in the spindle assembly checkpoint (SAC), the surveillance mechanism halting chromosome segregat...
ORGANISM(S): Saccharomyces cerevisiae 
2020-02-05 | GSE144741 | GEO
UnknownEffects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.
Not available
S-EPMC3760778 | biostudies-literature
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