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ProteomicsA CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism. Using unbiased interactomics, biochemical screening, molecula...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD043281 | Pride
Mitotic deprotection  cpc  shelterin  btr complex 
UnknownA non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection.
Not available
S-EPMC9837040 | biostudies-literature
UnknownA CPC-shelterin-BTR axis regulates mitotic telomere deprotection.
Not available
S-EPMC11914695 | biostudies-literature
UnknownReplication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.
Not available
S-EPMC6748914 | biostudies-literature
UnknownA telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest.
Not available
S-EPMC3319806 | biostudies-literature
UnknownProlonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival.
Not available
S-EPMC4882748 | biostudies-literature
UnknownMitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.
Not available
S-EPMC6363440 | biostudies-literature
TranscriptomicsTranscription profiling of acute telomere dysfunction in the mouse liver using adenoviral mediated, transient expression of a dominant negative version of TRF
Telomere dysfunction induces two types of cellular responses: cellular senescence and apoptosis. Here we analyzed the influence of the cellular level of telomere dysfunction and the role of p53 on induction of apoptosis and senescence in mouse liver using the experimental system of adenoviral mediat...
ORGANISM(S): Mus musculus 
2006-11-21 | E-MEXP-141 | biostudies-arrayexpress
UnknownCyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres.
Not available
S-EPMC4931922 | biostudies-literature
UnknownPhosphorylation status of MUS81 is a modifier of Olaparib sensitivity in BRCA2-deficient cells.
Not available
S-EPMC10359636 | biostudies-literature
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