Mitotic slippage

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Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest

Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signalling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here we show that multinucleate OIS cells originated mostly from failed mit...

ORGANISM(S): Homo sapiens

2015-08-13 | E-GEOD-70668 | biostudies-arrayexpress

Splicing factor CWC22 prevents tetraploidy formation and mitotic slippage through maintenance of the BubR1 expression and CDK1 activity

PRJNA1367080 | ENA

PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma.

Not available

S-EPMC4825548 | biostudies-literature

APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage.

Not available

S-EPMC3305350 | biostudies-literature

Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment.

Not available