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ProteomicsCopper depletion modulates OXPHOS in SOX2/OCT4+ cancer cells to impair triple negative breast cancer metastasis.
Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been associated with a significant survival benefit in high-risk triple negative breast cancer (TNBC) patients. Despite these...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-10-26 | PXD027089 | Pride
Metabolism Mitochondria Copper Oxphos Ampk Sox2/oct4+ cells Metastasis Triple negative breast cancer Tetrathiomolybdate 
TranscriptomicsTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
We sequenced mRNA from individual stormal cells (Macrophages, Monocytes, and Neutrophils) and tumor epithelial cells from KrasG12dD; p53-/- murine lung cancer model and WT control mouse to compare gene expressio profiles of lung cancer stroma and tumor cells to their counterparts of WT lugns. The tu...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59831 | biostudies-arrayexpress
TranscriptomicsDifferential expression of GFP+ and RFP+ TriPyMT cells
Tri-PyMT cell is a breast tumor cell line established from Tri-PyMT (MMTV-PyMT/fsp1-Cre/Rosa26-RGFP) primary breast tumors. The cells switch from RFP+ to GFP+ during epithelial to mesenchymal transition (EMT). Differential expressed genes between EMT and non-EMT tumor cells will reveal interesting t...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-72480 | biostudies-arrayexpress
UnknownClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Not available
S-EPMC6193486 | biostudies-literature
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