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MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11858 | MetaboLights
MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11844 | MetaboLights
TranscriptomicsThe Calcineurin-NFAT-Angiopoietin 2 signaling axis in lung endothelium is critical for the establishment of lung metastases
The pre-metastatic niche is a pre-determined site of metastases, awaiting the influx of tumor cells. Here we demonstrate that the calcineurin-NFAT pathway is activated specifically in lung endothelium prior to the detection of tumor cells that preferentially metastasize to the lung. We previously sh...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-48841 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for ANP in HUVEC
Analysis of HUVEC treated with ANP. ANP is a cardiac hormone, binding to the guanylate cyclase-A (GC-A) receptor with a major role in cardiovascular homeostatic mechanisms. Results provide insight into the molecular mechanisms of ANP in vascular endothelial cell. ANP induced gene expression in HUVEC...
ORGANISM(S): Homo sapiens 
2014-04-23 | E-GEOD-56976 | biostudies-arrayexpress
UnknownDecreased Abundance of Genus Slackia in Individuals With Obesity and Colorectal Adenoma.
Not available
S-EPMC11330935 | biostudies-literature
GenomicsGlobal analysis of NFATc1 binding and histone marks in VEGF-activated endothelial cells
We performed the newly mapping of genome-wide NFATc1 binding events in VEGF-stimulated primary cultured endothelial cells, by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). Combined NFATc1 ChIP-seq profile and the epigenetic histone marks revealed that predominant N...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-49428 | biostudies-arrayexpress
ProteomicsSialic Acid Linkage-Specific Alkylamidation-Based Method for Comprehensive N- and O-Glycoproteomic Profiling of Human Plasma
Sialic acids are attached to glycoproteins via alpha2,3- or alpha2,6-linkages and play important roles in disease pathogenesis. Sialyl linkage-specific derivatization of intact N- and/or O-glycopeptides remains challenging because of the diverse reactive functional groups within peptides. In this re...
ORGANISM(S): Homo Sapiens (human) 
2026-06-10 | PXD080569 | JPOST Repository
UnknownCommunity-Level Compact City Design, Health Care Provision, and Outcomes of Patients With Stroke.
Not available
S-EPMC12449981 | biostudies-literature
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