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GenomicsProfiling of CSDE1-bound RNAs under MKRN2-mediated ubiquitination
Profiling of CSDE1-bound RNAs under MKRN2-mediated ubiquitination
PRJNA1415271 | ENA
ProteomicsIdentification of ubiquitination sites on protein CSDE1 in SHSY5Y cells.
This bottom-up proteomics dataset provides a global map of post-translational modifications (PTMs) on the RNA-binding protein CSDE1 in human neuroblastoma SHSY5Y cells. The data was acquired to survey the modification landscape of CSDE1, with a particular observation that lysine (K) residues display...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD073844 | Pride
Mkrn2 Csde1 Ubiquitination site 
OtherProfiling of CSDE1-bound RNAs under MKRN2-mediated ubiquitination
This study aims to elucidate how MKRN2-mediated ubiquitination regulates the RNA-binding capacity of CSDE1. By overexpressing CSDE1 in MKRN2 knockout (KO) SHSY5Y cells and complementing with MKRN2 for comparison, we systematically analyzed the alterations in the RNA-binding repertoire of CSDE1 upon ...
ORGANISM(S): Homo sapiens 
2026-02-02 | GSE317793 | GEO
ProteomicsIdentifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking.
Utilisation of RNA-binding proteins (RBPs) is an important aspect of post-transcriptional regulation of viral RNA. Viruses such as influenza A viruses (IAV) interact with RBPs to regulate processes including splicing, nuclear export and trafficking, while also encoding RBPs within their genomes, suc...
ORGANISM(S): Homo sapiens (Human) 
2024-04-16 | PXD048870 | Pride
Influenza mkrn2 rna-binding 
GenomicsMKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development
MKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development
PRJNA562493 | ENA
GenomicsMKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development (RNA-Seq)
MKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development (RNA-Seq)
PRJNA562527 | ENA
OtherMKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development
The canonical mammalian mRNA export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through mRNP remodeling. We conducted a stringent affinity-purification mass-spectrometry-based screen of the physical interactions of human RNA-binding E3 ubiquitin ligases. The r...
ORGANISM(S): Homo sapiens 
2020-05-19 | GSE136399 | GEO
GenomicsThe RNA-binding E3 ligase MKRN2 selectively disrupts IL-6 translation to restrain inflammation
The RNA-binding E3 ligase MKRN2 selectively disrupts IL-6 translation to restrain inflammation
PRJNA1225624 | ENA
UnknownDeficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility.
Not available
S-EPMC5180214 | biostudies-literature
TranscriptomicsMKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development (RNA-Seq)
The canonical mammalian mRNA export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through mRNP remodeling. We conducted a stringent affinity-purification mass-spectrometry-based screen of the physical interactions of human RNA-binding E3 ubiquitin ligases. The r...
ORGANISM(S): Homo sapiens 
2020-05-19 | GSE136421 | GEO
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