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ProteomicsMlycd deficiency in Dahl salt-sensitive rats
Mlycd (malonyl-CoA decarboxylase) is a regulator of fatty acid metabolism. Lysine supplementation depletes kidney malonyl-CoA in hypertensive Dahl SS rats. As a key regulatory mechanism, lysine malonylation influences mitochondrial enzymes and fatty acid metabolism, with implications for CKD, hypert...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-12-14 | PXD062350 | Pride
Malonyl-coa Proteomics Mlycd Metabolomics 
TranscriptomicsDecreased mRNA expression of malonyl-CoA decarboxylase emerges from an inborn error-like defect in the Mlycd gene of DBA/2J mice
Mlycd encodes malonyl-CoA decarboxylase (MCD), which is an enzyme that localizes in the cytosolic, mitochondrial, and peroxisomal compartments and catalyzes the conversion of malonyl-CoA into acetyl-CoA. Malonyl-CoA can be converted into malonylcarnitine (C3DC). Patients with an autosomal recessive ...
ORGANISM(S): Mus musculus 
2024-10-26 | GSE186973 | GEO
GenomicsDecreased mRNA expression of malonyl-CoA decarboxylase emerges from an inborn error-like defect in the Mlycd gene of DBA/2J mice
Decreased mRNA expression of malonyl-CoA decarboxylase emerges from an inborn error-like defect in the Mlycd gene of DBA/2J mice
PRJNA777062 | ENA
UnknownCase report: A novel 5'-UTR-exon1-intron1 deletion in MLYCD in an IVF child with malonyl coenzyme A decarboxylase deficiency and literature review.
Not available
S-EPMC10189016 | biostudies-literature
Genomics
MLYCD mediated Fatty Acids Anabolism Represses Renal Cell Carcinoma Progression
PRJNA1014200 | ENA
Genomics
MLYCD mediated Fatty Acids Anabolism Represses Renal Cell Carcinoma Progression
PRJNA1014202 | ENA
ProteomicsMlycd deficiency in Dahl salt-sensitive rats
The dataset comprises targeted metabolomics data of kidney, liver, plasma and urine from Dahl salt-sensitive rats with and without Mlycd gene knockout. The analyzed metabolites include TCA cycle metabolites and lysine metabolites.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2025-05-14 | MSV000097897 | MassIVE
UnknownFatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression.
Not available
S-EPMC10690093 | biostudies-literature
UnknownMCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.
Not available
S-EPMC12808911 | biostudies-literature
UnknownInhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease.
Not available
S-EPMC3612370 | biostudies-literature
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