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ProteomicsEngineering controllable alteration of malonyl-CoA levels to enhance polyketide production
Heterologous expression of polyketide synthase (PKS) genes in Escherichia coli has enabled the production of various valuable natural and synthetic products. However, the limited availability of malonyl-CoA (M-CoA) in E. coli remains a significant impediment to high-titer polyketide production. In t...
ORGANISM(S): Escherichia coli 
2025-02-13 | PXD060741 | Pride
E. coli M-coa Pks Polyketides 
GenomicsIncreased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B
Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B
PRJNA724982 | ENA
ModelsOliveira2020 - Malonyl-CoA pathway for 3-hydroxypropionate production from glycerol
Malonyl-CoA pathway for 3-hydroxypropionate production from glycerol.
2020-10-19 | MODEL2010030008 | BioModels
ModelsOliveira2020 - Malonyl-CoA pathway for Acrylic Acid production from glycerol
Malonyl-CoA pathway for Acrylic Acid production from glycerol.
2020-10-19 | MODEL2010040007 | BioModels
ModelsOliveira2020 - Malonyl-CoA pathway for 3-hydroxypropionate production from glucose
Malonyl-CoA pathway for 3-hydroxypropionate production from glucose.
2020-10-19 | MODEL2010030006 | BioModels
Not Peer Reviewed 
ModelsOliveira2020 - Malonyl-CoA pathway for Acrylic Acid production from glucose
Malonyl-CoA pathway for Acrylic Acid production from glucose.
2020-10-19 | MODEL2010040006 | BioModels
Not Peer Reviewed 
TranscriptomicsIncreased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B
Mitochondrial fatty acid oxidation (FAO) is an important energy provider for cardiac work and changes in cardiac substrate preference are associated with different heart diseases. Carnitine palmitoyltransferase 1B (CPT1B) is thought to perform the rate limiting enzyme step in FAO and is inhibited by...
ORGANISM(S): Mus musculus 
2021-04-26 | GSE173256 | GEO
UnknownScreening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product.
Not available
S-EPMC5788913 | biostudies-literature
UnknownA Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA.
Not available
S-EPMC11463626 | biostudies-literature
UnknownHypothalamic malonyl-CoA as a mediator of feeding behavior.
Not available
S-EPMC240668 | biostudies-literature
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