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ProteomicsEngineering controllable alteration of malonyl-CoA levels to enhance polyketide production
Heterologous expression of polyketide synthase (PKS) genes in Escherichia coli has enabled the production of various valuable natural and synthetic products. However, the limited availability of malonyl-CoA (M-CoA) in E. coli remains a significant impediment to high-titer polyketide production. In t...
ORGANISM(S): Escherichia coli 
2025-02-13 | PXD060741 | Pride
E. coli M-coa Pks Polyketides 
TranscriptomicsEthylamine versus succinate cells of Methylobacterium extorquens
In order to provide global information on gene expression during growth on C2 compounds, microarray analysis of M. extorquens AM1 cells was carried out, comparing ethylamine-grown cells to succinate-grown cells. This comparison has confirmed previous observations on the inducible nature of some of t...
ORGANISM(S): Methylobacterium extorquens 
2010-05-14 | E-GEOD-20365 | biostudies-arrayexpress
UnknownCoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.
Not available
S-EPMC3259734 | biostudies-literature
ProteomicsLinking acetyl-CoA labelling and histone acetylation dynamics for accurate determination of acetylation rates via ordinary differential equations
To study complex biological systems, multi-omics methods have become an important tool. They integrate data from multiple biological layers, such as the metabolome and the proteome, to gain better insights of the processes happening. However, challenges remain both in sample preparation for measurem...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051487 | Pride
Human Lc-msms Acetylcoa Ptm Histone Acetylation Hek93t 
TranscriptomicsM. sedula transcriptional response under "strict" carbon-limited autotrophy compared to carbon "rich" autotrophy and heterotrophy
Metallosphaera sedula is an extremely thermoacidophilic archaeon that grows heterotrophically on peptides, and chemolithoautotrophically on hydrogen, sulfur, or reduced metals as energy sources. During autotrophic growth, carbon dioxide is incorporated into cellular carbon via the 3-hydroxypropionat...
ORGANISM(S): Metallosphaera sedula DSM 5348 
2013-03-05 | E-GEOD-39944 | biostudies-arrayexpress
ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080198 | MassIVE
UnknownExpression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].
Not available
S-EPMC3002352 | biostudies-literature
GenomicsThe metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling [ATAC-seq]
Metabolites and metabolic co-factors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor Coenzyme A (CoA) enhances IL-4 driven alternative macrophage activation [M(IL-4)] in vi...
ORGANISM(S): Mus musculus 
2026-03-13 | GSE324240 | GEO
TranscriptomicsThe metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling [RNA-seq]
Metabolites and metabolic co-factors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor Coenzyme A (CoA) enhances IL-4 driven alternative macrophage activation [M(IL-4)] in vi...
ORGANISM(S): Mus musculus 
2026-03-13 | GSE324239 | GEO
TranscriptomicsEthylamine versus succinate cells of Methylobacterium extorquens
In order to provide global information on gene expression during growth on C2 compounds, microarray analysis of M. extorquens AM1 cells was carried out, comparing ethylamine-grown cells to succinate-grown cells. This comparison has confirmed previous observations on the inducible nature of some of t...
ORGANISM(S): Methylorubrum extorquens AM1 Methylorubrum extorquens 
2010-02-22 | GSE20365 | GEO
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